¹H, ¹³C, and ¹⁵N backbone resonance assignments of the 37 kDa voltage-gated Ca²⁺ channel β4 subunit core SH3-GK domains.

The β subunit of the voltage-gated Ca(2+) channel (α1, α2δ, and β subunits) is a member of the MAGUK family of proteins and plays an essential role in regulating Ca(2+) channel trafficking and gating. It also serves as a central interaction partner for various Ca(2+) channel regulatory proteins. We report here the nearly complete (1)H, (13)C, and (15)N backbone resonance assignments of the 37 kDa core SH3-GK domains of the β4 subunit. This is the first report of solution assignments for β subunits, and as such will lay the foundation for future investigations of interaction site mapping, functional dynamics, and protein complex structure determination.