| Literature DB >> 23711834 |
Jagannath Jadhav1, Aarti Juvekar, Rajanikant Kurane, Sharanabasappa Khanapure, Rajashri Salunkhe, Gajanan Rashinkar.
Abstract
A novel series of ferrocene tagged multi-functionalized 1,4-dihydropyrimidines is synthesized by base catalyzed cyclocondensation between ferrocenyl chalcones and amidines. The structures of synthesized compounds were established on the basis of (1)H NMR, (13)C NMR, FTIR spectroscopy as well as by mass spectrometry. The compounds were evaluated for in vitro anticancer activity. The most active compounds from the series displayed GI50 value equal to doxorubicin against the strain of human breast cancer cell line MDA-MB-435.Entities:
Keywords: 1,4-Dihydropyrimidines; Amidines; Anti breast cancer activity; Ferrocenyl chalcones; Ferrrocene
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Year: 2013 PMID： 23711834 DOI： 10.1016/j.ejmech.2013.04.021
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514