Claudio Pelucchi1, Carlotta Galeone2, Jean-François Bach3, Carlo La Vecchia2, Liliane Chatenoud4. 1. IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. Electronic address: claudio.pelucchi@marionegri.it. 2. IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. 3. Université Paris Descartes, INSERM, Paris, France; INSERM, Unité 1013, Paris, France. 4. IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Abstract
BACKGROUND: Findings on pet exposure and the risk of atopic dermatitis (AD) in children are inconsistent. OBJECTIVE: With the aim to summarize the results of exposure to different pets on AD, we undertook a meta-analysis of epidemiologic studies on this issue. METHODS: In August 2012, we conducted a systematic literature search in Medline and Embase. We included analytic studies considering exposure to dogs, cats, other pets, or pets overall during pregnancy, infancy, and/or childhood, with AD assessment performed during infancy or childhood. We calculated summary relative risks and 95% CIs using both fixed- and random-effects models. We computed summary estimates across selected subgroups. RESULTS: Twenty-six publications from 21 birth cohort studies were used in the meta-analyses. The pooled relative risks of AD for exposure versus no exposure were 0.72 (95% CI, 0.61-0.85; I(2) = 46%; results based on 15 studies) for exposure to dogs, 0.94 (95% CI, 0.76-1.16; I(2) = 54%; results based on 13 studies) for exposure to cats, and 0.75 (95% CI, 0.67-0.85; I(2) = 54%; results based on 11 studies) for exposure to pets overall. No heterogeneity emerged across the subgroups examined, except for geographic area. CONCLUSION: This meta-analysis reported a favorable effect of exposure to dogs and pets on the risk of AD in infants or children, whereas no association emerged with exposure to cats.
BACKGROUND: Findings on pet exposure and the risk of atopic dermatitis (AD) in children are inconsistent. OBJECTIVE: With the aim to summarize the results of exposure to different pets on AD, we undertook a meta-analysis of epidemiologic studies on this issue. METHODS: In August 2012, we conducted a systematic literature search in Medline and Embase. We included analytic studies considering exposure to dogs, cats, other pets, or pets overall during pregnancy, infancy, and/or childhood, with AD assessment performed during infancy or childhood. We calculated summary relative risks and 95% CIs using both fixed- and random-effects models. We computed summary estimates across selected subgroups. RESULTS: Twenty-six publications from 21 birth cohort studies were used in the meta-analyses. The pooled relative risks of AD for exposure versus no exposure were 0.72 (95% CI, 0.61-0.85; I(2) = 46%; results based on 15 studies) for exposure to dogs, 0.94 (95% CI, 0.76-1.16; I(2) = 54%; results based on 13 studies) for exposure to cats, and 0.75 (95% CI, 0.67-0.85; I(2) = 54%; results based on 11 studies) for exposure to pets overall. No heterogeneity emerged across the subgroups examined, except for geographic area. CONCLUSION: This meta-analysis reported a favorable effect of exposure to dogs and pets on the risk of AD in infants or children, whereas no association emerged with exposure to cats.
Authors: A R Sitarik; S Havstad; A M Levin; S V Lynch; K E Fujimura; D R Ownby; C C Johnson; G Wegienka Journal: Indoor Air Date: 2018-03-13 Impact factor: 5.770
Authors: Cancan Qi; Yale Jiang; Ivana V Yang; Erick Forno; Ting Wang; Judith M Vonk; Ulrike Gehring; Henriëtte A Smit; Edith B Milanzi; Orestes A Carpaij; Marijn Berg; Laura Hesse; Sharon Brouwer; Jonathan Cardwell; Cornelis J Vermeulen; Edna Acosta-Pérez; Glorisa Canino; Nadia Boutaoui; Maarten van den Berge; Sarah A Teichmann; Martijn C Nawijn; Wei Chen; Juan C Celedón; Cheng-Jian Xu; Gerard H Koppelman Journal: J Allergy Clin Immunol Date: 2020-01-14 Impact factor: 10.793
Authors: Marissa T Ayasse; Adnan Ahmed; Maria L Espinosa; Christina J Walker; Muhammad Yousaf; Jacob P Thyssen; Jonathan I Silverberg Journal: Arch Dermatol Res Date: 2020-11-22 Impact factor: 3.017