Literature DB >> 23711372

Scavenger receptor B1 post-translational modifications in Rett syndrome.

Claudia Sticozzi1, Giuseppe Belmonte, Alessandra Pecorelli, Franco Cervellati, Silvia Leoncini, Cinzia Signorini, Lucia Ciccoli, Claudio De Felice, Joussef Hayek, Giuseppe Valacchi.   

Abstract

The modulation of the HDL receptor scavenger receptor B1 (SRB1) was evaluated in skin fibroblasts isolated from patients with Rett syndrome (RTT), a genetic form of infantile autism. Patients showed an altered plasma lipid profile, while their skin fibroblasts showed a dramatic reduction in SRB1 (immunogold, Western blot and immunohistochemistry). The decreased SRB1 levels were demonstrated to be the consequence of its binding with 4-hydroxy-2-nonenal (4HNE), a product of lipid peroxidation, and its increased ubiquitination. Our findings show for the first time a loss of SRB1 in RTT cells and its relationship with a chronic oxidative stress status.
Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2013        PMID： 23711372     DOI： 10.1016/j.febslet.2013.05.042

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  24 in total

1.  A protocol for evaluation of Rett Syndrome symptom improvement by metabolic modulators in Mecp2-mutant mice.

Authors:  Christie M Buchovecky; Misty G Hill; Jennifer M Borkey; Stephanie M Kyle; Monica J Justice
Journal:  Curr Protoc Mouse Biol       Date:  2013

2.  A role for metabolism in Rett syndrome pathogenesis: New clinical findings and potential treatment targets.

Authors:  Monica J Justice; Christie M Buchovecky; Stephanie M Kyle; Aleksandra Djukic
Journal:  Rare Dis       Date:  2013-12-18

3.  Alteration of serum lipid profile, SRB1 loss, and impaired Nrf2 activation in CDKL5 disorder.

Authors:  Alessandra Pecorelli; Giuseppe Belmonte; Ilaria Meloni; Franco Cervellati; Concetta Gardi; Claudia Sticozzi; Claudio De Felice; Cinzia Signorini; Alessio Cortelazzo; Silvia Leoncini; Lucia Ciccoli; Alessandra Renieri; Henry Jay Forman; Joussef Hayek; Giuseppe Valacchi
Journal:  Free Radic Biol Med       Date:  2015-05-22       Impact factor: 7.376

Review 4.  Rett syndrome: think outside the (skull) box.

Authors:  Emilie Borloz; Laurent Villard; Jean-Christophe Roux
Journal:  Fac Rev       Date:  2021-06-29

5.  Effect of combined mulberry leaf and fruit extract on liver and skin cholesterol transporters in high fat diet-induced obese mice.

Authors:  Giuseppe Valacchi; Giuseppe Belmonte; Clelia Miracco; Hyeyoon Eo; Yunsook Lim
Journal:  Nutr Res Pract       Date:  2014-01-29       Impact factor: 1.926

6.  Inflammatory lung disease in Rett syndrome.

Authors:  Claudio De Felice; Marcello Rossi; Silvia Leoncini; Glauco Chisci; Cinzia Signorini; Giuseppina Lonetti; Laura Vannuccini; Donatella Spina; Alessandro Ginori; Ingrid Iacona; Alessio Cortelazzo; Alessandra Pecorelli; Giuseppe Valacchi; Lucia Ciccoli; Tommaso Pizzorusso; Joussef Hayek
Journal:  Mediators Inflamm       Date:  2014-03-17       Impact factor: 4.711

7.  Effects of ω-3 polyunsaturated fatty acids on plasma proteome in Rett syndrome.

Authors:  Claudio De Felice; Alessio Cortelazzo; Cinzia Signorini; Roberto Guerranti; Silvia Leoncini; Alessandra Pecorelli; Thierry Durand; Jean-Marie Galano; Camille Oger; Gloria Zollo; Barbara Montomoli; Claudia Landi; Luca Bini; Giuseppe Valacchi; Lucia Ciccoli; Joussef Hayek
Journal:  Mediators Inflamm       Date:  2013-12-09       Impact factor: 4.711

8.  Genes related to mitochondrial functions, protein degradation, and chromatin folding are differentially expressed in lymphomonocytes of Rett syndrome patients.

Authors:  Alessandra Pecorelli; Guido Leoni; Franco Cervellati; Raffaella Canali; Cinzia Signorini; Silvia Leoncini; Alessio Cortelazzo; Claudio De Felice; Lucia Ciccoli; Joussef Hayek; Giuseppe Valacchi
Journal:  Mediators Inflamm       Date:  2013-12-12       Impact factor: 4.711

9.  Effects of ω-3 PUFAs supplementation on myocardial function and oxidative stress markers in typical Rett syndrome.

Authors:  Silvia Maffei; Claudio De Felice; Pierpaolo Cannarile; Silvia Leoncini; Cinzia Signorini; Alessandra Pecorelli; Barbara Montomoli; Stefano Lunghetti; Lucia Ciccoli; Thierry Durand; Roberto Favilli; Joussef Hayek
Journal:  Mediators Inflamm       Date:  2014-01-12       Impact factor: 4.711

10.  Subclinical inflammatory status in Rett syndrome.

Authors:  Alessio Cortelazzo; Claudio De Felice; Roberto Guerranti; Cinzia Signorini; Silvia Leoncini; Alessandra Pecorelli; Gloria Zollo; Claudia Landi; Giuseppe Valacchi; Lucia Ciccoli; Luca Bini; Joussef Hayek
Journal:  Mediators Inflamm       Date:  2014-01-06       Impact factor: 4.711
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