Literature DB >> 23709675

Stearoyl co-A desaturase 1 as a ccRCC therapeutic target: death by stress.

Janet Y Leung1, William Y Kim.   

Abstract

There is a need for the discovery of novel therapeutic strategies to effectively treat advanced clear cell renal cell carcinoma (ccRCC). Inhibition of stearoyl-coA desaturase 1 (SCD1) in ccRCC reveals antitumor activity, independently and in synergy with mTOR inhibition. SCD1 may be a potential novel therapeutic target in treating ccRCC.

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Year:  2013        PMID： 23709675      PMCID： PMC3898854          DOI： 10.1158/1078-0432.CCR-13-0800

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  10 in total

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Authors:  William Y Kim; William G Kaelin
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Authors:  Stéphane J H Ricoult; Brendan D Manning
Journal:  EMBO Rep       Date:  2012-02-12       Impact factor: 8.807

Review 3.  Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer.

Authors:  R Ariel Igal
Journal:  Carcinogenesis       Date:  2010-07-01       Impact factor: 4.944

4.  Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia.

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Journal:  Nature       Date:  2011-11-20       Impact factor: 49.962

Review 5.  The role of the unfolded protein response in tumour development: friend or foe?

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Journal:  Nat Rev Cancer       Date:  2004-12       Impact factor: 60.716

Review 6.  Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis.

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Journal:  Nat Rev Cancer       Date:  2007-10       Impact factor: 60.716

7.  HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption.

Authors:  Ioanna Papandreou; Rob A Cairns; Lucrezia Fontana; Ai Lin Lim; Nicholas C Denko
Journal:  Cell Metab       Date:  2006-03       Impact factor: 27.287

8.  HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.

Authors:  Jung-whan Kim; Irina Tchernyshyov; Gregg L Semenza; Chi V Dang
Journal:  Cell Metab       Date:  2006-03       Impact factor: 27.287

9.  Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.

Authors:  Christina A von Roemeling; Laura A Marlow; Johnny J Wei; Simon J Cooper; Thomas R Caulfield; Kevin Wu; Winston W Tan; Han W Tun; John A Copland
Journal:  Clin Cancer Res       Date:  2013-04-30       Impact factor: 12.531

10.  Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1.

Authors:  G L Semenza; B H Jiang; S W Leung; R Passantino; J P Concordet; P Maire; A Giallongo
Journal:  J Biol Chem       Date:  1996-12-20       Impact factor: 5.157
  10 in total
  6 in total

Review 1.  Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment.

Authors:  Daniel Ackerman; M Celeste Simon
Journal:  Trends Cell Biol       Date:  2014-07-04       Impact factor: 20.808

2.  Inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances the antitumor T cell response through regulating β-catenin signaling in cancer cells and ER stress in T cells and synergizes with anti-PD-1 antibody.

Authors:  Yuki Katoh; Tomonori Yaguchi; Akiko Kubo; Takashi Iwata; Kenji Morii; Daiki Kato; Shigeki Ohta; Ryosuke Satomi; Yasuhiro Yamamoto; Yoshitaka Oyamada; Kota Ouchi; Shin Takahashi; Chikashi Ishioka; Ryo Matoba; Makoto Suematsu; Yutaka Kawakami
Journal:  J Immunother Cancer       Date:  2022-07       Impact factor: 12.469

3.  High Expression of Stearoyl-CoA Desaturase 1 Predicts Poor Prognosis in Patients with Clear-Cell Renal Cell Carcinoma.

Authors:  Jianfeng Wang; Yunze Xu; Liangsong Zhu; Yun Zou; Wen Kong; Baijun Dong; Jiwei Huang; Yonghui Chen; Wei Xue; Yiran Huang; Jin Zhang
Journal:  PLoS One       Date:  2016-11-18       Impact factor: 3.240

Review 4.  Curbing Lipids: Impacts ON Cancer and Viral Infection.

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Journal:  Int J Mol Sci       Date:  2019-02-02       Impact factor: 5.923

Review 5.  A novel approach to the discovery of anti-tumor pharmaceuticals: searching for activators of liponecrosis.

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Journal:  Oncotarget       Date:  2016-02-02

6.  Systems biology of ferroptosis: A modeling approach.

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Journal:  J Theor Biol       Date:  2020-02-28       Impact factor: 2.691
  6 in total

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