OBJECTIVE: To evaluate correlations between longitudinal changes in neuro-ophthalmologic measures and quality of life (QOL) and disability in patients with multiple sclerosis (MS), using optical coherence tomography (OCT), visual evoked potentials (VEP), and visual field examination. METHODS: Fifty-four patients with relapsing-remitting MS were enrolled in this study and underwent Multiple Sclerosis Quality of Life questionnaire (54 items) (MSQOL-54) and Expanded Disability Status Scale (EDSS) evaluation, as well as complete neuro-ophthalmologic examination including visual field testing and retinal nerve fiber layer (RNFL) measurements using Cirrus and Spectralis OCT and VEP. All patients were re-evaluated at 12, 24, and 36 months. Logistical regression was performed to analyze which measures, if any, could predict QOL. RESULTS: Overall, RNFL thickness results at the baseline evaluation were significantly different from those at 3 years (p ≤ 0.05), but there were no differences in functional measures (visual acuity, contrast sensitivity, color vision, visual field, and VEP). A reduced MSQOL-54 score was associated with an increase in EDSS score and a decrease in both functional and structural parameters. Patients with longer MS duration presented with a lower MSQOL-54 score (reduction in QOL). CONCLUSIONS: Patients with progressive axonal loss as seen in RNFL results had a lower QOL and more functional disability.
OBJECTIVE: To evaluate correlations between longitudinal changes in neuro-ophthalmologic measures and quality of life (QOL) and disability in patients with multiple sclerosis (MS), using optical coherence tomography (OCT), visual evoked potentials (VEP), and visual field examination. METHODS: Fifty-four patients with relapsing-remitting MS were enrolled in this study and underwent Multiple Sclerosis Quality of Life questionnaire (54 items) (MSQOL-54) and Expanded Disability Status Scale (EDSS) evaluation, as well as complete neuro-ophthalmologic examination including visual field testing and retinal nerve fiber layer (RNFL) measurements using Cirrus and Spectralis OCT and VEP. All patients were re-evaluated at 12, 24, and 36 months. Logistical regression was performed to analyze which measures, if any, could predict QOL. RESULTS: Overall, RNFL thickness results at the baseline evaluation were significantly different from those at 3 years (p ≤ 0.05), but there were no differences in functional measures (visual acuity, contrast sensitivity, color vision, visual field, and VEP). A reduced MSQOL-54 score was associated with an increase in EDSS score and a decrease in both functional and structural parameters. Patients with longer MS duration presented with a lower MSQOL-54 score (reduction in QOL). CONCLUSIONS:Patients with progressive axonal loss as seen in RNFL results had a lower QOL and more functional disability.
Authors: T Sartoretti; E Sartoretti; S Rauch; C Binkert; M Wyss; D Czell; S Sartoretti-Schefer Journal: AJNR Am J Neuroradiol Date: 2017-06-29 Impact factor: 3.825
Authors: V Polo; E Garcia-Martin; M P Bambo; J Pinilla; J M Larrosa; M Satue; S Otin; L E Pablo Journal: Eye (Lond) Date: 2014-03-14 Impact factor: 3.775
Authors: Amir H Kashani; Samuel Asanad; Jane W Chan; Maxwell B Singer; Jiong Zhang; Mona Sharifi; Maziyar M Khansari; Farzan Abdolahi; Yonggang Shi; Alessandro Biffi; Helena Chui; John M Ringman Journal: Prog Retin Eye Res Date: 2021-01-15 Impact factor: 19.704
Authors: V Polo; M Satue; M J Rodrigo; S Otin; R Alarcia; M P Bambo; M I Fuertes; J M Larrosa; L E Pablo; E Garcia-Martin Journal: BMJ Open Date: 2016-05-06 Impact factor: 2.692
Authors: Maria Satue; Maria Jesus Rodrigo; Sofia Otin; Maria Pilar Bambo; Maria Isabel Fuertes; Jose Ramon Ara; Jesus Martin; Vicente Polo; Jose Manuel Larrosa; Luis Pablo; Elena Garcia-Martin Journal: PLoS One Date: 2016-06-28 Impact factor: 3.240
Authors: Rachel C Nolan; Steven L Galetta; Teresa C Frohman; Elliot M Frohman; Peter A Calabresi; Carmen Castrillo-Viguera; Diego Cadavid; Laura J Balcer Journal: J Neuroophthalmol Date: 2018-12 Impact factor: 3.042