Literature DB >> 237091

A simultaneous determination of acetylsalicylic acid, salicylic acid and salicylamide in plasma by gas liquid chromatography.

M J Rance, B J Jordan, J D Nichols.   

Abstract

A novel method for the simultaneous determination of acetylsalicylic acid, salicylic acid and salicylamide in biological fluids by gas liquid chromatography is described. The assay has been used to determine the plasma concentration of salicylates in 10 volunteers after oral ingestion of three commercially available aspirin-containing formulations. No difficulty was encountered in determining low concentrations of acetylsalicylic acid in the presence of higher concentrations of salicylic acid. The in vivo plasma half life of acetylsalicylic acid in man was found to be 15.5 min.

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Year:  1975        PMID： 237091     DOI： 10.1111/j.2042-7158.1975.tb09472.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  6 in total

1.  An evaluation of buffered aspirin and aspirin tablets in postoperative pain after third molar surgery.

Authors:  R A Seymour; M Weldon; P Kelly; E Nicholson; J E Hawkesford
Journal:  Br J Clin Pharmacol       Date:  1992-04       Impact factor: 4.335

2.  An evaluation of different doses of soluble aspirin and aspirin tablets in postoperative dental pain.

Authors:  I S Holland; R A Seymour; R P Ward-Booth; R A Ord; K L Lim; R C Hoare
Journal:  Br J Clin Pharmacol       Date:  1988-10       Impact factor: 4.335

3.  Decreased cyclooxygenase inhibition by aspirin in polymorphic variants of human prostaglandin H synthase-1.

Authors:  Wen Liu; Elizabeth M Poole; Cornelia M Ulrich; Richard J Kulmacz
Journal:  Pharmacogenet Genomics       Date:  2012-07       Impact factor: 2.089

4.  Comparative efficacy of soluble aspirin and aspirin tablets in postoperative dental pain.

Authors:  R A Seymour; F M Williams; N M Luyk; M A Boyle; P M Whitfield; E Nicholson; P W Booth; M D Rawlins
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

5.  Monitoring plasma concentrations of salicylate.

Authors:  M Mandelli; G Tognoni
Journal:  Clin Pharmacokinet       Date:  1980 Sep-Oct       Impact factor: 6.447

6.  Efficacy and pharmacokinetics of aspirin in post-operative dental pain.

Authors:  R A Seymour; M D Rawlins
Journal:  Br J Clin Pharmacol       Date:  1982-06       Impact factor: 4.335
  6 in total

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