Daniel K Roberts1, Tricia L Newman, Mary F Roberts, Jacob T Wilensky. 1. *Department of Clinical Education, Illinois Eye Institute, Illinois College of Optometry and Departments of †Epidemiology and Biostatistics ‡Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL.
Abstract
PURPOSE: To investigate presence of remnants of the tunica vasculosa lentis, a possible indication of anterior segment dysgenesis, in subjects with the long anterior zonule (LAZ) trait. METHODS: Retroillumination photographs of the pupil region had been collected in earlier study of the LAZ trait in African Americans. Secondary image analysis was performed to assess the frequency of intact persistent pupillary membrane iris strands (PPMIS). RESULTS: The analysis included 148 subjects, comprised of 74 LAZ subjects (median age=70 y; range, 50 to 91 y; 64 females) and 74 controls (68 y; 50 to 83 y; 64 females). While controlling for age and sex, analysis showed that LAZ subjects were 3.1 times more likely than controls (odds ratio=3.1; 95% confidence interval, 1.4-6.7; P=0.004) to exhibit PPMIS in at least one of their eyes. CONCLUSION: The LAZ trait, which is being studied as a potential risk factor for glaucoma, was associated with presence of PPMIS in our study population.
PURPOSE: To investigate presence of remnants of the tunica vasculosa lentis, a possible indication of anterior segment dysgenesis, in subjects with the long anterior zonule (LAZ) trait. METHODS: Retroillumination photographs of the pupil region had been collected in earlier study of the LAZ trait in African Americans. Secondary image analysis was performed to assess the frequency of intact persistent pupillary membrane iris strands (PPMIS). RESULTS: The analysis included 148 subjects, comprised of 74 LAZ subjects (median age=70 y; range, 50 to 91 y; 64 females) and 74 controls (68 y; 50 to 83 y; 64 females). While controlling for age and sex, analysis showed that LAZ subjects were 3.1 times more likely than controls (odds ratio=3.1; 95% confidence interval, 1.4-6.7; P=0.004) to exhibit PPMIS in at least one of their eyes. CONCLUSION: The LAZ trait, which is being studied as a potential risk factor for glaucoma, was associated with presence of PPMIS in our study population.
Authors: Radha Ayyagari; Md Nawajes A Mandal; Athanasios J Karoukis; Lianchun Chen; Ning C McLaren; Mona Lichter; David T Wong; Peter F Hitchcock; Rafael C Caruso; Sayoko E Moroi; Irene H Maumenee; Paul A Sieving Journal: Invest Ophthalmol Vis Sci Date: 2005-09 Impact factor: 4.799
Authors: Visvaraja Subrayan; Brid Morris; Ana Maria Armbrecht; Alan F Wright; Baljean Dhillon Journal: Am J Ophthalmol Date: 2005-12 Impact factor: 5.258
Authors: Daniel K Roberts; Janis Ecklund Winters; David D Castells; Bruce A Teitelbaum; Cathy Clark Alexander Journal: J Glaucoma Date: 2005-02 Impact factor: 2.503
Authors: Daniel K Roberts; Yongyi Yang; Christina E Morettin; Tricia L Newman; Mary F Roberts; Jacob T Wilensky Journal: Anat Rec (Hoboken) Date: 2017-02-25 Impact factor: 2.064
Authors: Daniel K Roberts; Yongyi Yang; Christina E Morettin; Trinh Doan; Tricia L Newman; Jacob T Wilensky Journal: Clin Exp Ophthalmol Date: 2015-07-01 Impact factor: 4.207
Authors: Daniel K Roberts; Tricia L Newman; Mary Flynn Roberts; Bruce A Teitelbaum; Janis E Winters Journal: Invest Ophthalmol Vis Sci Date: 2018-04-01 Impact factor: 4.799