| Literature DB >> 23708142 |
Elizabeth M Bradshaw1, Lori B Chibnik, Brendan T Keenan, Linda Ottoboni, Towfique Raj, Anna Tang, Laura L Rosenkrantz, Selina Imboywa, Michelle Lee, Alina Von Korff, Martha C Morris, Denis A Evans, Keith Johnson, Reisa A Sperling, Julie A Schneider, David A Bennett, Philip L De Jager.
Abstract
In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444(C) risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, P(joint) = 1.3 × 10(-13)) of young and older individuals. It was also associated with diminished internalization of amyloid-β 42 peptide, accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging, and increased numbers of activated human microglia.Entities:
Mesh：
Substances：
Year: 2013 PMID： 23708142 PMCID： PMC3703870 DOI： 10.1038/nn.3435
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884