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Literature DB >> 23708141

Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume.

Grégory Conductier¹, Frédéric Brau, Angèle Viola, Fanny Langlet, Navean Ramkumar, Bénédicte Dehouck, Thibault Lemaire, Raphaël Chapot, Laurianne Lucas, Carole Rovère, Priscilla Maitre, Salma Hosseiny, Agnès Petit-Paitel, Antoine Adamantidis, Bernard Lakaye, Pierre-Yves Risold, Vincent Prévot, Olivier Meste, Jean-Louis Nahon, Alice Guyon.

Abstract

Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.

Entities: Disease Gene Species

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Year: 2013 PMID： 23708141 DOI： 10.1038/nn.3401

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

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