| Literature DB >> 23707845 |
Izumi Kushibuchi1, Miho Kobayashi, Takashi Kusaka, Hiroyuki Tsukagoshi, Akihide Ryo, Ayako Yoshida, Haruyuki Ishii, Takeshi Saraya, Daisuke Kurai, Norio Yamamoto, Kazuhiko Kanou, Mika Saitoh, Masahiro Noda, Makoto Kuroda, Yukio Morita, Kunihisa Kozawa, Kazunori Oishi, Masato Tashiro, Hirokazu Kimura.
Abstract
We investigated the evolution of the C-terminal 3rd hypervariable region of G gene in the prevalent human respiratory syncytial virus (RSV) subgroups A (RSV-A) and B (RSV-B) in Japan in 2008-2011. Phylogenetic analysis and the evolutionary timescale was obtained by the Bayesian Markov Chain Monte Carlo method. All 38 RSV-A strains detected were classified into genotype NA1 and the 17 RSV-B strains detected belonged to genotypes BA and GB2. NA1 subdivided around 1998 in the present phylogenetic tree. Genotype BA subdivided around 1994. The evolutionary rates for RSV-A and RSV-B were estimated at 3.63×10⁻³ and 4.56×10⁻³ substitutions/site/year, respectively. The mean evolutionary rate of RSV-B was significantly faster than that of RSV-A during all seasons. The pairwise distance was relatively short (less than 0.06). In addition, some unique sites under positive selection were found. The results suggested that this region of the RSV strains rapidly evolved with some unique amino acid substitutions due to positive pressure.Entities:
Keywords: ARI; Bayesian Markov Chain Monte Carlo method; ESS; FEL; G gene; HPD; IFEL; MCMC; Markov Chain Monte Carlo; Pairwise distance; Positively selected site; REL; RSV; Respiratory syncytial virus; SLAC; Time-scaled phylogeny; acute respiratory infection; effective sample size; fixed effects likelihood; highest posterior density; internal fixed effects likelihood; random effects likelihood; respiratory syncytial virus; single likelihood ancestor counting; tMRCA; time of the most recent common ancestor
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Year: 2013 PMID： 23707845 DOI： 10.1016/j.meegid.2013.05.010
Source DB: PubMed Journal: Infect Genet Evol ISSN： 1567-1348 Impact factor: 3.342