Literature DB >> 23707398

ABC-cassette transporter 1 (ABCA1) expression in epithelial cells in Chlamydia pneumoniae infection.

Juha T Korhonen1, Vesa M Olkkonen, Riitta Lahesmaa, Mirja Puolakkainen.   

Abstract

ATP-binding cassette transporter A1 (ABCA1) mediates reverse cholesterol transport and innate immunity response in different cell types. We have investigated the regulation of ABCA1 expression in response to intracellular Chlamydia pneumoniae infection in A549 epithelial lung carcinoma cells. C. pneumoniae infection decreased ABCA1 expression in A549 cells, and the activity of the ABCA1 promoter was decreased. The decreased promoter activity was dependent on its E-box and GnT-box elements of the promoter. Chlamydial growth was decreased in ABCA1-silenced epithelial lung carcinoma cells. These data indicate an important role for ABCA1 in intracellular bacterial infection.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  ABCA1; Chlamydia pneumoniae; Epithelial cells

Mesh：

Substances：

Year:  2013        PMID： 23707398     DOI： 10.1016/j.micpath.2013.05.006

Source DB:  PubMed          Journal:  Microb Pathog        ISSN： 0882-4010            Impact factor:   3.738


  8 in total

Review 1.  Infection with Chlamydia pneumoniae as a cause of coronary heart disease: the hypothesis is still untested.

Authors:  J Thomas Grayston; Robert J Belland; Gerald I Byrne; Cho Chou Kuo; Julius Schachter; Walter E Stamm; Guangming Zhong
Journal:  Pathog Dis       Date:  2014-12-04       Impact factor: 3.166

Review 2.  Manipulation of Host Cholesterol by Obligate Intracellular Bacteria.

Authors:  Dhritiman Samanta; Minal Mulye; Tatiana M Clemente; Anna V Justis; Stacey D Gilk
Journal:  Front Cell Infect Microbiol       Date:  2017-05-05       Impact factor: 5.293

Review 3.  Chlamydial Infection From Outside to Inside.

Authors:  Arlieke Gitsels; Niek Sanders; Daisy Vanrompay
Journal:  Front Microbiol       Date:  2019-10-09       Impact factor: 5.640

Review 4.  The Role of ABC Transporters in Lipid Metabolism and the Comorbid Course of Chronic Obstructive Pulmonary Disease and Atherosclerosis.

Authors:  Stanislav Kotlyarov; Anna Kotlyarova
Journal:  Int J Mol Sci       Date:  2021-06-23       Impact factor: 5.923

5.  Literature-Informed Analysis of a Genome-Wide Association Study of Gestational Age in Norwegian Women and Children Suggests Involvement of Inflammatory Pathways.

Authors:  Jonas Bacelis; Julius Juodakis; Verena Sengpiel; Ge Zhang; Ronny Myhre; Louis J Muglia; Staffan Nilsson; Bo Jacobsson
Journal:  PLoS One       Date:  2016-08-04       Impact factor: 3.240

6.  Plasma Membrane Profiling Reveals Upregulation of ABCA1 by Infected Macrophages Leading to Restriction of Mycobacterial Growth.

Authors:  Jing Long; Robindra Basu Roy; Yanjia J Zhang; Robin Antrobus; Yuxian Du; Duncan L Smith; Michael P Weekes; Babak Javid
Journal:  Front Microbiol       Date:  2016-07-12       Impact factor: 5.640

Review 7.  Regulation of ATP binding cassette transporter A1 (ABCA1) expression: cholesterol-dependent and - independent signaling pathways with relevance to inflammatory lung disease.

Authors:  Patrick He; Ingrid C Gelissen; Alaina J Ammit
Journal:  Respir Res       Date:  2020-09-25

Review 8.  Participation of ABCA1 Transporter in Pathogenesis of Chronic Obstructive Pulmonary Disease.

Authors:  Stanislav Kotlyarov
Journal:  Int J Mol Sci       Date:  2021-03-24       Impact factor: 5.923
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.