| Literature DB >> 23706474 |
Kim Beerhorst1, Sylvie J M van der Kruijs, Pauline Verschuure, I Y Francis Tan, Albert P Aldenkamp.
Abstract
An increasing number of studies suggest a direct effect of antiepileptic drug (AED) therapy on bone health: Patients on chronic AED therapy may have an increased risk of fractures, reduced bone mineral density, osteopenia, and osteoporosis. In an attempt to distinguish general and specific risk factors, this review examines the available empirical research. The pathophysiology is discussed and guidelines for early detection and treatment options are proposed.Entities:
Keywords: Anticonvulsant; Bone disease; Bone mineral density; Epilepsy; Fracture risk; Osteopenia; Osteoporosis; Rickets
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Year: 2013 PMID： 23706474 DOI： 10.1016/j.jns.2013.05.005
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181