OBJECTIVE: To investigate differences in sepsis mortality between prepubertal and postpubertal males and females. STUDY DESIGN: This was a retrospective review of the Virtual PICU Systems (VPS) database (including 74 pediatric intensive care units [PICUs]) for 2006-2008. We included prepubertal (aged 2-7 years) and postpubertal (aged 16-21 years) children with a primary diagnosis of sepsis admitted to a participating PICU. RESULTS: Prepubertal females (n = 272; 9.9% mortality) and prepubertal males (n = 303; 10.9% mortality) had similar mortality and severity of illness (Pediatric Index of Mortality 2 risk of mortality [PIM 2 ROM]). Postpubertal females (n = 233; mortality, 5.6%) had lower mortality than postpubertal males (n = 212; mortality, 11.8%; P = .03). PIM 2 ROM was higher for postpubertal males than postpubertal females (P = .02). After controlling for hospital specific effects with multivariate modeling, in postpubertal children, female gender was independently associated with a lower initial severity of illness (PIM 2 ROM: OR, 0.77; 95% CI, 0.62-0.96; P = .02). CONCLUSION: Sepsis mortality is similar in prepubertal males and females. However, postpubertal males have a higher sepsis mortality than postpubertal females, likely related to their greater severity of illness on PICU admission. These outcome differences in postpubertal children may reflect a hormonal influence on the response to infection or differences in underlying comorbidities, source of infection, or behavior.
OBJECTIVE: To investigate differences in sepsis mortality between prepubertal and postpubertal males and females. STUDY DESIGN: This was a retrospective review of the Virtual PICU Systems (VPS) database (including 74 pediatric intensive care units [PICUs]) for 2006-2008. We included prepubertal (aged 2-7 years) and postpubertal (aged 16-21 years) children with a primary diagnosis of sepsis admitted to a participating PICU. RESULTS: Prepubertal females (n = 272; 9.9% mortality) and prepubertal males (n = 303; 10.9% mortality) had similar mortality and severity of illness (Pediatric Index of Mortality 2 risk of mortality [PIM 2 ROM]). Postpubertal females (n = 233; mortality, 5.6%) had lower mortality than postpubertal males (n = 212; mortality, 11.8%; P = .03). PIM 2 ROM was higher for postpubertal males than postpubertal females (P = .02). After controlling for hospital specific effects with multivariate modeling, in postpubertal children, female gender was independently associated with a lower initial severity of illness (PIM 2 ROM: OR, 0.77; 95% CI, 0.62-0.96; P = .02). CONCLUSION:Sepsis mortality is similar in prepubertal males and females. However, postpubertal males have a higher sepsis mortality than postpubertal females, likely related to their greater severity of illness on PICU admission. These outcome differences in postpubertal children may reflect a hormonal influence on the response to infection or differences in underlying comorbidities, source of infection, or behavior.
Authors: G Twig; N Geva; H Levine; E Derazne; N Goldberger; Z Haklai; A Leiba; J D Kark Journal: Int J Obes (Lond) Date: 2017-10-30 Impact factor: 5.095
Authors: Tellen D Bennett; Michael C Spaeder; Renée I Matos; R Scott Watson; Katri V Typpo; Robinder G Khemani; Sheri Crow; Brian D Benneyworth; Ravi R Thiagarajan; J Michael Dean; Barry P Markovitz Journal: Front Pediatr Date: 2014-07-29 Impact factor: 3.418
Authors: Jianmin Chen; Fausto Chiazza; Massimo Collino; Nimesh S A Patel; Sina M Coldewey; Christoph Thiemermann Journal: PLoS One Date: 2014-06-19 Impact factor: 3.240
Authors: Anna M Kosyreva; Dzhuliia Sh Dzhalilova; Olga V Makarova; Ivan S Tsvetkov; Natalia A Zolotova; Marina A Diatroptova; Elena A Ponomarenko; Vladimir A Mkhitarov; Dmitriy N Khochanskiy; Liliya P Mikhailova Journal: Sci Rep Date: 2020-09-28 Impact factor: 4.379