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Literature DB >> 23706163

Genetic dissection of ventral folding morphogenesis in mouse: embryonic visceral endoderm-supplied BMP2 positions head and heart.

Abstract

Ventral folding morphogenesis (VFM), a vital morphogenetic process in amniotes, mediates gut endoderm internalization, linear heart tube formation, ventral body wall closure and encasement of the fetus in extraembryonic membranes. Aberrant VFM underlies a number of birth defects such as gastroschisis and ectopia cordis in human and misplacement of head and heart in mouse. Recent cell lineage-specific mouse mutant analyses identified the Bone Morphogenetic Protein (BMP) pathway and Anterior Visceral Endoderm (AVE) as key regulators of anterior VFM. Loss of BMP2 expression solely from embryonic visceral endoderm (EmVE) and the AVE blocks formation of foregut invagination, and simultaneously, aberrantly positions the heart anterior/dorsal to the head, suggesting a mechanistic link between foregut and head/heart morphogenesis.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2013 PMID： 23706163 PMCID： PMC3759531 DOI： 10.1016/j.gde.2013.04.001

Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578

42 in total

1. Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning.

Authors: Daniel Mesnard; Marcela Guzman-Ayala; Daniel B Constam
Journal: Development Date: 2006-05-25 Impact factor: 6.868

Review 2. Gene function in mouse embryogenesis: get set for gastrulation.

Authors: Patrick P L Tam; David A F Loebel
Journal: Nat Rev Genet Date: 2007-03-27 Impact factor: 53.242

3. The embryology of body wall closure: relevance to gastroschisis and other ventral body wall defects.

Authors: T W Sadler; Marcia L Feldkamp
Journal: Am J Med Genet C Semin Med Genet Date: 2008-08-15 Impact factor: 3.908

4. Animal models of ventral body wall closure defects: a personal perspective on gastroschisis.

Authors: Trevor Williams
Journal: Am J Med Genet C Semin Med Genet Date: 2008-08-15 Impact factor: 3.908

5. Regionalisation of the endoderm progenitors and morphogenesis of the gut portals of the mouse embryo.

Authors: Vanessa Franklin; Poh Lynn Khoo; Heidi Bildsoe; Nicole Wong; Samara Lewis; Patrick P L Tam
Journal: Mech Dev Date: 2008-04-11 Impact factor: 1.882

Review 6. The embryologic origin of ventral body wall defects.

Authors: Thomas W Sadler
Journal: Semin Pediatr Surg Date: 2010-08 Impact factor: 2.754

7. The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages.

Authors: Gloria S Kwon; Manuel Viotti; Anna-Katerina Hadjantonakis
Journal: Dev Cell Date: 2008-10 Impact factor: 12.270

8. Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis.

Authors: Kazushi Aoto; Yayoi Shikata; Hajime Imai; Daisuke Matsumaru; Tomoyuki Tokunaga; Seiji Shioda; Gen Yamada; Jun Motoyama
Journal: Dev Biol Date: 2008-12-07 Impact factor: 3.582

9. Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3.

Authors: Silvia Maretto; Pari-Sima Müller; A Radu Aricescu; Ken W Y Cho; Elizabeth K Bikoff; Elizabeth J Robertson
Journal: Dev Biol Date: 2008-03-26 Impact factor: 3.582

10. Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo.

Authors: Masamichi Yamamoto; Hideyuki Beppu; Katsuyoshi Takaoka; Chikara Meno; En Li; Kohei Miyazono; Hiroshi Hamada
Journal: J Cell Biol Date: 2009-01-19 Impact factor: 10.539

10 in total

Genetic dissection of ventral folding morphogenesis in mouse: embryonic visceral endoderm-supplied BMP2 positions head and heart.

1. Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning.

Review 2. Gene function in mouse embryogenesis: get set for gastrulation.

3. The embryology of body wall closure: relevance to gastroschisis and other ventral body wall defects.

4. Animal models of ventral body wall closure defects: a personal perspective on gastroschisis.

5. Regionalisation of the endoderm progenitors and morphogenesis of the gut portals of the mouse embryo.

Review 6. The embryologic origin of ventral body wall defects.

7. The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages.

8. Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis.

9. Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3.

10. Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo.

1. Characterization of new bone morphogenetic protein (Bmp)-2 regulatory alleles.

Review 2. Convergent extension in mammalian morphogenesis.

3. The Fetus with Ectopia Cordis: Experience and Expectations from Two Centers.

Review 4. PTIP-Associated Protein 1: More Than a Component of the MLL3/4 Complex.

5. Novel copy-number variants in a population-based investigation of classic heterotaxy.

6. Scribble mutation disrupts convergent extension and apical constriction during mammalian neural tube closure.

7. Prenatal diagnosis of a rare isolated thoracic-type ectopia cordis with complete form: a case report.

Review 8. The endoderm: a divergent cell lineage with many commonalities.

Review 9. Embryology of the Abdominal Wall and Associated Malformations-A Review.

10. Mutant cohesin affects RNA polymerase II regulation in Cornelia de Lange syndrome.