Literature DB >> 2370551

Liver, brain, and heart metallothionein induction by stress.

J Hidalgo1, M Borrás, J S Garvey, A Armario.   

Abstract

To date, stress has been reported to induce metallothionein (MT) synthesis in the liver only. In the present experiment, the effects of food and water deprivation alone or of immobilization stress plus food and water deprivation on liver, brain, and heart MT have been studied in adult male rats. Liver and brain MT levels were increased by immobilization stress as soon as 6 h after the onset of stress. Eighteen hours of immobilization, which is accompanied by food and water deprivation, further increased liver and brain MT levels and significantly increased heart MT content. A specific effect of immobilization was evident in all three tissues, because the effect of food and water deprivation alone was significantly lower than that of immobilization plus starvation. Changes in MT apparently were not related to changes in cytosolic Zn.

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Year:  1990        PMID： 2370551     DOI： 10.1111/j.1471-4159.1990.tb04182.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  16 in total

Review 1.  Induction of metallothionein by stress and its molecular mechanisms.

Authors:  S T Jacob; K Ghoshal; J F Sheridan
Journal:  Gene Expr       Date:  1999

2.  CNS wound healing is severely depressed in metallothionein I- and II-deficient mice.

Authors:  M Penkowa; J Carrasco; M Giralt; T Moos; J Hidalgo
Journal:  J Neurosci       Date:  1999-04-01       Impact factor: 6.167

Review 3.  Metallothionein in the central nervous system: Roles in protection, regeneration and cognition.

Authors:  Adrian K West; Juan Hidalgo; Donnie Eddins; Edward D Levin; Michael Aschner
Journal:  Neurotoxicology       Date:  2008-01-19       Impact factor: 4.294

Review 4.  Metallothionein and brain inflammation.

Authors:  Yasmina Manso; Paul A Adlard; Javier Carrasco; Milan Vašák; Juan Hidalgo
Journal:  J Biol Inorg Chem       Date:  2011-06-16       Impact factor: 3.358

Review 5.  Metallothionein and stress combine to affect multiple organ systems.

Authors:  Michael A Lynes; Juan Hidalgo; Yasmina Manso; Lindsey Devisscher; Debby Laukens; David A Lawrence
Journal:  Cell Stress Chaperones       Date:  2014-03-02       Impact factor: 3.667

6.  Effect of stress, adrenalectomy and changes in glutathione metabolism on rat kidney metallothionein content: comparison with liver metallothionein.

Authors:  M Giralt; T Gasull; J Hernandez; A Garcia; J Hidalgo
Journal:  Biometals       Date:  1993       Impact factor: 2.949

7.  Studies on the metabolism of metallothionein and alkaline phosphatase of adult rat primary hepatocyte cultures: role of fetal calf serum and agonists of the phosphoinositide cascade.

Authors:  K Krämer; A Markwitan; J Pallauf
Journal:  Z Ernahrungswiss       Date:  1993-09

8.  Metallothionein-I induction by stress in specific brain areas.

Authors:  J Hidalgo; L Campmany; O Martí; A Armario
Journal:  Neurochem Res       Date:  1991-10       Impact factor: 3.996

9.  Identification of a signal transducer and activator of transcription (STAT) binding site in the mouse metallothionein-I promoter involved in interleukin-6-induced gene expression.

Authors:  D K Lee; J Carrasco; J Hidalgo; G K Andrews
Journal:  Biochem J       Date:  1999-01-01       Impact factor: 3.857

10.  Metallothionein induction reduces caspase-3 activity and TNFalpha levels with preservation of cognitive function and intact hippocampal neurons in carmustine-treated rats.

Authors:  Gouda K Helal; Abdulaziz M Aleisa; Omayma K Helal; Salim S Al-Rejaie; Abdulaziz A Al-Yahya; Abdulhakeem A Al-Majed; Othman A Al-Shabanah
Journal:  Oxid Med Cell Longev       Date:  2009 Jan-Mar       Impact factor: 6.543
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