Literature DB >> 23703283

Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor.

Luigi Margarucci1, Maria Chiara Monti, Chiara Cassiano, Matteo Mozzicafreddo, Mauro Angeletti, Raffaele Riccio, Alessandra Tosco, Agostino Casapullo.   

Abstract

Hsp90, a key target in cancer therapy, has been identified as the main partner of oleocanthal, an olive oil bioactive compound. A combination of chemical and biological assays disclosed its mechanism of action at the molecular level.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23703283     DOI： 10.1039/c3cc41858h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  14 in total

1.  The olive oil phenolic (-)-oleocanthal modulates estrogen receptor expression in luminal breast cancer in vitro and in vivo and synergizes with tamoxifen treatment.

Authors:  Nehad M Ayoub; Abu Bakar Siddique; Hassan Y Ebrahim; Mohamed M Mohyeldin; Khalid A El Sayed
Journal:  Eur J Pharmacol       Date:  2017-06-15       Impact factor: 4.432

2.  The saponin D39 blocks dissociation of non-muscular myosin heavy chain IIA from TNF receptor 2, suppressing tissue factor expression and venous thrombosis.

Authors:  Ke-Feng Zhai; Jin-Rong Zheng; You-Mei Tang; Fang Li; Yan-Ni Lv; Yuan-Yuan Zhang; Zhen Gao; Jin Qi; Bo-Yang Yu; Jun-Ping Kou
Journal:  Br J Pharmacol       Date:  2017-07-18       Impact factor: 8.739

3.  N-Formyl-7-amino-11-cycloamphilectene, a marine sponge metabolite, binds to tubulin and modulates microtubule depolymerization.

Authors:  Luigi Margarucci; Maria Chiara Monti; Roberta Esposito; Alessandra Tosco; Ernest Hamel; Raffaele Riccio; Agostino Casapullo
Journal:  Mol Biosyst       Date:  2014-02-04

4.  Olive Oil-derived Oleocanthal as Potent Inhibitor of Mammalian Target of Rapamycin: Biological Evaluation and Molecular Modeling Studies.

Authors:  Mohammad A Khanfar; Sanaa K Bardaweel; Mohamed R Akl; Khalid A El Sayed
Journal:  Phytother Res       Date:  2015-08-07       Impact factor: 5.878

5.  Olive phenolics as c-Met inhibitors: (-)-Oleocanthal attenuates cell proliferation, invasiveness, and tumor growth in breast cancer models.

Authors:  Mohamed R Akl; Nehad M Ayoub; Mohamed M Mohyeldin; Belnaser A Busnena; Ahmed I Foudah; Yong-Yu Liu; Khalid A Ei Sayed
Journal:  PLoS One       Date:  2014-05-21       Impact factor: 3.240

Review 6.  Targeting Cell Survival Proteins for Cancer Cell Death.

Authors:  Manoj K Pandey; Sahdeo Prasad; Amit Kumar Tyagi; Lokesh Deb; Jiamin Huang; Deepkamal N Karelia; Shantu G Amin; Bharat B Aggarwal
Journal:  Pharmaceuticals (Basel)       Date:  2016-02-25

Review 7.  The Biological Activities of Oleocanthal from a Molecular Perspective.

Authors:  Kok-Lun Pang; Kok-Yong Chin
Journal:  Nutrients       Date:  2018-05-06       Impact factor: 5.717

8.  Carbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite.

Authors:  Sara Ceccacci; Jana Deitersen; Matteo Mozzicafreddo; Elva Morretta; Peter Proksch; Sebastian Wesselborg; Björn Stork; Maria Chiara Monti
Journal:  Biomolecules       Date:  2020-06-02

Review 9.  Oleocanthal, a phenolic derived from virgin olive oil: a review of the beneficial effects on inflammatory disease.

Authors:  Lisa Parkinson; Russell Keast
Journal:  Int J Mol Sci       Date:  2014-07-11       Impact factor: 5.923

10.  Discovering the Biological Target of 5-epi-Sinuleptolide Using a Combination of Proteomic Approaches.

Authors:  Elva Morretta; Roberta Esposito; Carmen Festa; Raffaele Riccio; Agostino Casapullo; Maria Chiara Monti
Journal:  Mar Drugs       Date:  2017-10-13       Impact factor: 5.118
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.