Literature DB >> 23702794

High-pressure, compact, modular radiosynthesizer for production of positron emitting biomarkers.

Bernard Amaraesekera1, Phillip D Marchis, Krzysztof P Bobinski, Caius G Radu, Johannes Czernin, Jorge R Barrio, R Michael van Dam.   

Abstract

A robust, modular, semi-automated synthesis unit useful for conducting radiochemical reactions under pressurized conditions (up to ∼200psi [1.4MPa]) for the production of PET biomarkers has been developed. This compact unit (7.6cm×33.0cm×58.4cm) is capable of performing any single step reaction that is generally encountered in radiochemical syntheses, and multiple units can be combined for more complex syntheses. The versatility of a 3-unit system is exemplified by reliably conducting the multi-step syntheses of 2'-deoxy-2'-[(18)F]fluoro-1-β-arabinofuranosyl-uracil and -cytosine derivatives, which involve corrosive and moisture sensitive reagents under pressurized conditions.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23702794     DOI： 10.1016/j.apradiso.2013.04.024

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  9 in total

1.  Production of diverse PET probes with limited resources: 24 18F-labeled compounds prepared with a single radiosynthesizer.

Authors:  Jeffrey Collins; Christopher M Waldmann; Christopher Drake; Roger Slavik; Noel S Ha; Maxim Sergeev; Mark Lazari; Bin Shen; Frederick T Chin; Melissa Moore; Saman Sadeghi; Michael E Phelps; Jennifer M Murphy; R Michael van Dam
Journal:  Proc Natl Acad Sci U S A       Date:  2017-10-10       Impact factor: 11.205

2.  Ring opening of epoxides with [18F]FeF species to produce [18F]fluorohydrin PET imaging agents.

Authors:  Stefan Verhoog; Allen F Brooks; Wade P Winton; Benjamin L Viglianti; Melanie S Sanford; Peter J H Scott
Journal:  Chem Commun (Camb)       Date:  2019-05-30       Impact factor: 6.222

3.  Plug-and-play modules for flexible radiosynthesis.

Authors:  Henry Herman; Graciela Flores; Kevin Quinn; Mark Eddings; Sebastian Olma; Melissa D Moore; Huijiang Ding; Krzysztof P Bobinski; Mingwei Wang; Dirk Williams; Darin Wiliams; Clifton Kwang-Fu Shen; Michael E Phelps; R Michael van Dam
Journal:  Appl Radiat Isot       Date:  2013-04-25       Impact factor: 1.513

4.  Fully automated production of diverse 18F-labeled PET tracers on the ELIXYS multireactor radiosynthesizer without hardware modification.

Authors:  Mark Lazari; Jeffrey Collins; Bin Shen; Mohammed Farhoud; Daniel Yeh; Brandon Maraglia; Frederick T Chin; David A Nathanson; Melissa Moore; R Michael van Dam
Journal:  J Nucl Med Technol       Date:  2014-07-17

5.  Compact microfluidic device for rapid concentration of PET tracers.

Authors:  Wei-Yu Tseng; R Michael van Dam
Journal:  Lab Chip       Date:  2014-07-07       Impact factor: 6.799

6.  Simplified programming and control of automated radiosynthesizers through unit operations.

Authors:  Shane B Claggett; Kevin M Quinn; Mark Lazari; Melissa D Moore; R Michael van Dam
Journal:  EJNMMI Res       Date:  2013-07-15       Impact factor: 3.138

Review 7.  18F-labelled intermediates for radiosynthesis by modular build-up reactions: newer developments.

Authors:  Johannes Ermert
Journal:  Biomed Res Int       Date:  2014-06-23       Impact factor: 3.411

8.  ELIXYS - a fully automated, three-reactor high-pressure radiosynthesizer for development and routine production of diverse PET tracers.

Authors:  Mark Lazari; Kevin M Quinn; Shane B Claggett; Jeffrey Collins; Gaurav J Shah; Henry E Herman; Brandon Maraglia; Michael E Phelps; Melissa D Moore; R Michael van Dam
Journal:  EJNMMI Res       Date:  2013-07-12       Impact factor: 3.138

9.  Development and implementation of ISAR, a new synthesis platform for radiopharmaceutical production.

Authors:  Christopher Frank; Georg Winter; Fredrik Rensei; Victor Samper; Allen F Brooks; Brian G Hockley; Bradford D Henderson; Christian Rensch; Peter J H Scott
Journal:  EJNMMI Radiopharm Chem       Date:  2019-09-18
  9 in total

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