| Literature DB >> 23702250 |
Anna-Martha V Fontanari1, Tahiana Andreazza, Ângelo B Costa, Jaqueline Salvador, Walter J Koff, Bianca Aguiar, Pamela Ferrari, Raffael Massuda, Mariana Pedrini, Esalba Silveira, Paulo S Belmonte-de-Abreu, Clarissa S Gama, Marcia Kauer-Sant'Anna, Flavio Kapczinski, Maria Ines R Lobato.
Abstract
Gender Identity Disorder (GID) is characterized by a strong and persistent cross-gender identification that affects different aspects of behavior. Brain-derived neurotrophic factor (BDNF) plays a critical role in neurodevelopment and neuroplasticity. Altered BDNF-signaling is thought to contribute to the pathogenesis of psychiatric disordersand is related to traumatic life events. To examine serum BDNF levels, we compared one group of DSM-IV GID patients (n = 45) and one healthy control group (n = 66). Serum BDNF levels were significantly decreased in GID patients (p = 0.013). This data support the hypothesis that the reduction found in serum BDNF levels in GID patients may be related to the psychological abuse that transsexuals are exposed during their life.Entities:
Keywords: Brain-derived neurotrophic factor; Gender identity disorder; Transsexualism
Mesh：
Substances：
Year: 2013 PMID： 23702250 DOI： 10.1016/j.jpsychires.2013.04.012
Source DB: PubMed Journal: J Psychiatr Res ISSN： 0022-3956 Impact factor: 4.791