| Literature DB >> 23701133 |
Yasumitsu Hirose1, Hiroaki Suefuji, Hayato Kaida, Masanobu Hayakawa, Satoshi Hattori, Seiji Kurata, Yuko Watanabe, Yukiko Kunou, Akihiko Kawahara, Takashi Okamura, Koichi Ohshima, Masayoshi Kage, Masatoshi Ishibashi, Naofumi Hayabuchi.
Abstract
The aim of this study was to investigate correlations between the standardized uptake value of the biopsy site (BSUVmax) and levels of glucose transporter (GLUT)-1, GLUT-3 and hexokinase-II (HK-II), between BSUVmax and the Ki-67 proliferation index (MIB-1), and between BSUVmax and clinicopathological factors. Sixty-eight patients with diffuse large B-cell lymphoma (DLBCL) were included in this study. BSUVmax was significantly correlated with GLUT-1, GLUT-3 and the International Prognostic Index (IPI) (GLUT-1: r = 0.584, IPI: r = 0.363, p < 0.001; GLUT-3: r = 0.369, p = 0.009; IPI: r = 0.363, p = 0.004), but not with MIB-1 and HK-II. A statistically significant correlation was observed between GLUT-3 expression and each of IPI and gene expression profiling (GEP) (IPI: p = 0.0186; GEP: p = 0.0179). 2-Deoxy-2-[(18)F]-fluoro-d-glucose (FDG) uptake was significantly correlated with the levels of GLUT-1 and GLUT-3 and with IPI. The results indicated that GLUT-3 expression is related to GEP and IPI, and that BSUVmax and GLUT-3 may have a relationship with the prognosis of DLBCL.Entities:
Mesh：
Substances：
Year: 2013 PMID： 23701133 DOI： 10.3109/10428194.2013.807509
Source DB: PubMed Journal: Leuk Lymphoma ISSN： 1026-8022