| Literature DB >> 23700973 |
Matthäus Getlik1, Brian J Wilson, M Monzur Morshed, Iain D G Watson, Doris Tang, Pandiaraju Subramanian, Rima Al-awar.
Abstract
The reaction of 3-halo-4-aminopyridines with acyl chlorides and triethylamine is described. The pyridin-4-yl α-substituted acetamide products were obtained in moderate to high yields. The presented rearrangement reaction, in which the presumed N-acylated intermediate reacts intramolecularly via nucleophilic aromatic substitution, results in a formal two-carbon insertion.Entities:
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Year: 2013 PMID： 23700973 DOI： 10.1021/jo4003773
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354