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Literature DB >> 2370081

Post-transcriptional regulation of complement C4 in low C4-producing strain of mouse.

K Nakayama¹, S Pattanakitsakul, S Yokoyama, H Kimura, M Nonaka, M Takahashi.

Abstract

The expression of the fourth component of complement (C4) of the mouse can differ 20-fold and is determined by C4-high (C4h) or C4-low (C4l) alleles. To investigate the molecular mechanisms underlying the differences in C4 expression, we compared the transcriptional activity of the C4 genes between high and low C4-producer strains of mice (B10 and FM vs B10.BR) using nuclear transcriptional and chloramphenicol acetyltransferase (CAT) assays. We also compared the level of C4-specific RNA in total and nuclear RNA of the liver. The results revealed no significant difference in transcriptional activity between C4h and C4l genes. However, the steady-state levels of C4 mRNA are ten times lower in C4l strains than in C4h strains, suggesting that the major regulation of C4 plasma levels occurs at the post-transcriptional level.

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Year: 1990 PMID： 2370081 DOI： 10.1007/bf02115011

Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846

39 in total

1. Alternative splicing directs the expression of two D2 dopamine receptor isoforms.

Authors: B Giros; P Sokoloff; M P Martres; J F Riou; L J Emorine; J C Schwartz
Journal: Nature Date: 1989 Dec 21-28 Impact factor: 49.962

Review 2. Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.

Authors: M Nonaka; K Nakayama; Y D Yeul; A Shimizu; M Takahashi
Journal: Immunol Rev Date: 1985-10 Impact factor: 12.988

3. GM-CSF and oncogene mRNA stabilities are independently regulated in trans in a mouse monocytic tumor.

Authors: G D Schuler; M D Cole
Journal: Cell Date: 1988-12-23 Impact factor: 41.582

4. Cell-free synthesis of the fourth component of guinea pig complement (C4): identification of a precursor of serum C4 (pro-C4).

Authors: R E Hall; H R Colten
Journal: Proc Natl Acad Sci U S A Date: 1977-04 Impact factor: 11.205

Review 5. The S region of the mouse major histocompatibility complex (H-2): genetic variation and functional role in complement system.

Authors: D C Shreffler
Journal: Transplant Rev Date: 1976

6. Structural characterization of the murine fourth component of complement and sex-limited protein and their precursors: evidence for two loci in the S region of the H-2 complex.

Authors: K L Parker; M H Roos; D C Shreffler
Journal: Proc Natl Acad Sci U S A Date: 1979-11 Impact factor: 11.205

7. The evolution of alpha-fetoprotein and albumin. II. The structures of the alpha-fetoprotein and albumin genes in the mouse.

Authors: D Kioussis; F Eiferman; P van de Rijn; M B Gorin; R S Ingram; S M Tilghman
Journal: J Biol Chem Date: 1981-02-25 Impact factor: 5.157

8. Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

Authors: R T Ogata; D S Sepich
Journal: Proc Natl Acad Sci U S A Date: 1984-08 Impact factor: 11.205

9. In vitro packaging of a lambda Dam vector containing EcoRI DNA fragments of Escherichia coli and phage P1.

Authors: N Sternberg; D Tiemeier; L Enquist
Journal: Gene Date: 1977-05 Impact factor: 3.688

10. Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.

Authors: M Nonaka; H Kimura; Y D Yeul; S Yokoyama; K Nakayama; M Takahashi
Journal: Proc Natl Acad Sci U S A Date: 1986-10 Impact factor: 11.205

7 in total

Post-transcriptional regulation of complement C4 in low C4-producing strain of mouse.

1. Alternative splicing directs the expression of two D2 dopamine receptor isoforms.

Review 2. Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.

3. GM-CSF and oncogene mRNA stabilities are independently regulated in trans in a mouse monocytic tumor.

4. Cell-free synthesis of the fourth component of guinea pig complement (C4): identification of a precursor of serum C4 (pro-C4).

Review 5. The S region of the mouse major histocompatibility complex (H-2): genetic variation and functional role in complement system.

6. Structural characterization of the murine fourth component of complement and sex-limited protein and their precursors: evidence for two loci in the S region of the H-2 complex.

7. The evolution of alpha-fetoprotein and albumin. II. The structures of the alpha-fetoprotein and albumin genes in the mouse.

8. Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

9. In vitro packaging of a lambda Dam vector containing EcoRI DNA fragments of Escherichia coli and phage P1.

10. Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.

1. Insertion of the B2 sequence into intron 13 is the only defect of the H-2k C4 gene which causes low C4 production.

2. New nucleotide sequence data on the EMBL File Server.

3. Thy-1 is not transcribed in the Thy-1- g mutant and in Thy-1- interlineage hybrids.

4. Differential expression of the five C4-related genes of H-2w7 mice.

5. Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

6. DNase I hypersensitivity mapping and promoter polymorphism analysis of human C4.

7. Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.