Dan Lv1, Shixi Liu, Rong Yu, Yuanzhi Zhu, Hui Yang. 1. Department of Otolaryngology Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Abstract
OBJECTIVE: To investigate the histogenesis, morphological features and biologic behaviors of granular cell tumor(GCT) of the larynx. METHOD: A retrospective study was performed in three cases of GCT in our hospital, the clinical data were studied with histopathologic analysis, histochemical and immunohistochemical staining, and combining with the analysis of domestic and foreign literatures. RESULT: Histopathologic features of laryngeal GCT were identical to that in soft tissues, but pseudoepitheliomatous hyperplasia was present in 50%-60% cases of the tumor. This disease may originate from the neurogenic Schwann cell, S-100 could be positive in immunohistochemistry. CONCLUSION: Laryngeal GCT is a rare benign tumor and can be cured by local excision.
OBJECTIVE: To investigate the histogenesis, morphological features and biologic behaviors of granular cell tumor(GCT) of the larynx. METHOD: A retrospective study was performed in three cases of GCT in our hospital, the clinical data were studied with histopathologic analysis, histochemical and immunohistochemical staining, and combining with the analysis of domestic and foreign literatures. RESULT: Histopathologic features of laryngeal GCT were identical to that in soft tissues, but pseudoepitheliomatous hyperplasia was present in 50%-60% cases of the tumor. This disease may originate from the neurogenic Schwann cell, S-100 could be positive in immunohistochemistry. CONCLUSION: Laryngeal GCT is a rare benign tumor and can be cured by local excision.