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Literature DB >> 2370055

Human alpha B-crystallin (CRYA2) gene mapped to chromosome 11q12-q23.

R H Brakenhoff¹, A H Guerts van Kessel, M Oldenburg, J T Wijnen, H Bloemendal, P Meera Khan, J G Schoenmakers.

Abstract

The alpha B-crystallin gene (CRYA2) encodes the abundant lens protein alpha B-crystallin. A panel of human/rodent hybrid cell lines, derived from five different parental combinations, was characterized with respect to human chromosomal content and the presence of well-established human chromosome-specific markers. This panel was screened for the presence of CRYA2, using the third exon of the hamster alpha B-crystallin gene as a probe. The patterns of segregation of CRYA2 with individual human chromosomes show the highest degree of concordance between CRYA2 and chromosome 11. Using cell hybrids containing translocated and/or partially deleted human chromosomes, the CRYA2 gene was localized to 11q12-11q23.

Entities: Gene Species

Mesh：

Substances：
Crystallins

Year: 1990 PMID： 2370055 DOI： 10.1007/bf00193203

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

14 in total

1. The eye lens crystallins: ambiguity as evolutionary strategy.

Authors: W W de Jong; W Hendriks
Journal: J Mol Evol Date: 1986 Impact factor: 2.395

2. Report of the committee on the genetic constitution of chromosomes 10, 11, and 12.

Authors: H H Kazazian; C Junien
Journal: Cytogenet Cell Genet Date: 1987

3. Enzyme electrophoresis on cellulose acetate gel: zymogram patterns in mgh-mouse and man--Chinese hamster somatic cell hybrids.

Authors: P Meera Khan
Journal: Arch Biochem Biophys Date: 1971-08 Impact factor: 4.013

4. Lens crystallins and their gene families.

Authors: J Piatigorsky
Journal: Cell Date: 1984-10 Impact factor: 41.582

Review 5. Lens proteins.

Authors: H Bloemendal
Journal: CRC Crit Rev Biochem Date: 1982

6. Regional localization of DNA probes on the short arm of chromosome 11 using aniridia-Wilms' tumor-associated deletions.

Authors: M Mannens; R M Slater; C Heyting; A Geurts van Kessel; E Goedde-Salz; R R Frants; G J Van Ommen; P L Pearson
Journal: Hum Genet Date: 1987-02 Impact factor: 4.132

7. A locus for a human hereditary cataract is closely linked to the gamma-crystallin gene family.

Authors: N H Lubsen; J H Renwick; L C Tsui; M L Breitman; J G Schoenmakers
Journal: Proc Natl Acad Sci U S A Date: 1987-01 Impact factor: 11.205

8. Expression of human myeloid-associated surface antigens in human-mouse myeloid cell hybrids.

Authors: A H Geurts van Kessel; P A Tetteroo; A E von dem Borne; A Hagemeijer; D Bootsma
Journal: Proc Natl Acad Sci U S A Date: 1983-06 Impact factor: 11.205

9. Hu-ets-1 and Hu-ets-2 genes are transposed in acute leukemias with (4;11) and (8;21) translocations.

Authors: N Sacchi; D K Watson; A H Guerts van Kessel; A Hagemeijer; J Kersey; H D Drabkin; D Patterson; T S Papas
Journal: Science Date: 1986-01-24 Impact factor: 47.728

10. Localization of human myeloid-associated surface antigen detected by a panel of 20 monoclonal antibodies to the q12-qter region of chromosome 11.

Authors: A G van Kessel; P Tetteroo; T van Agthoven; R Paulussen; J van Dongen; A Hagemeijer; A von dem Borne
Journal: J Immunol Date: 1984-09 Impact factor: 5.422

7 in total

7. The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion.

Authors: R H Brakenhoff; M Gerretsen; E M Knippels; M van Dijk; H van Essen; D O Weghuis; R J Sinke; G B Snow; G A van Dongen
Journal: J Cell Biol Date: 1995-06 Impact factor: 10.539

7 in total

Human alpha B-crystallin (CRYA2) gene mapped to chromosome 11q12-q23.

1. The eye lens crystallins: ambiguity as evolutionary strategy.

2. Report of the committee on the genetic constitution of chromosomes 10, 11, and 12.

3. Enzyme electrophoresis on cellulose acetate gel: zymogram patterns in mgh-mouse and man--Chinese hamster somatic cell hybrids.

4. Lens crystallins and their gene families.

Review 5. Lens proteins.

6. Regional localization of DNA probes on the short arm of chromosome 11 using aniridia-Wilms' tumor-associated deletions.

7. A locus for a human hereditary cataract is closely linked to the gamma-crystallin gene family.

8. Expression of human myeloid-associated surface antigens in human-mouse myeloid cell hybrids.

9. Hu-ets-1 and Hu-ets-2 genes are transposed in acute leukemias with (4;11) and (8;21) translocations.

10. Localization of human myeloid-associated surface antigen detected by a panel of 20 monoclonal antibodies to the q12-qter region of chromosome 11.

Review 1. A superfamily in the mammalian eye lens: the beta/gamma-crystallins.

2. Intermediate filament diseases: desminopathy.

3. Identification of a lens-specific regulatory region (LSR) of the murine alpha B-crystallin gene.

4. Subregional physical mapping of an alpha B-crystallin sequence and of a new expressed sequence D11S877E to human 11q.

5. Construction and characterization of the chimeric monoclonal antibody E48 for therapy of head and neck cancer.

Review 6. Tragedy in a heartbeat: malfunctioning desmin causes skeletal and cardiac muscle disease.

7. The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion.