BACKGROUND: Few studies on the occurrence of depression in pediatric patients with chronic kidney disease (CKD) have been conducted and none have identified associated clinical and demographic factors. METHODS: This was a cross-sectional study in which we administered the Child Depression Inventory-2 (CDI-2) to 44 patients aged 9-18 years with CKD stages III-V. Criteria for depression were CDI-2 scores of ≥65 or an established diagnosis of depression recorded in the medical chart. Relative risks (RR) and 95 % confidence intervals (CI) were calculated to determine associations between patient characteristics and depression status. RESULTS: Of the 44 patients enrolled in the study, 13 (30 %) met our criteria for depression, representing 18 % of patients aged <13 years and 34 % of those aged ≥13 years. Although not reaching statistical significance, the adjusted risk of depression was lower for patients with CKD duration of ≤3 years than for those with longer CKD duration (RR 0.19, 95 % CI 0.02, 1.53), and for those with CKD stage IV (RR 0.23, 95 % CI 0.05, 1.09) and CKD stage V (RR 0.13, 95 % CI 0.01, 1.07) compared to those with CKD stage III. CONCLUSIONS: Our results indicate that depression is common in children with CKD, particularly for those with longstanding renal disease and at CKD stage III.
BACKGROUND: Few studies on the occurrence of depression in pediatric patients with chronic kidney disease (CKD) have been conducted and none have identified associated clinical and demographic factors. METHODS: This was a cross-sectional study in which we administered the ChildDepression Inventory-2 (CDI-2) to 44 patients aged 9-18 years with CKD stages III-V. Criteria for depression were CDI-2 scores of ≥65 or an established diagnosis of depression recorded in the medical chart. Relative risks (RR) and 95 % confidence intervals (CI) were calculated to determine associations between patient characteristics and depression status. RESULTS: Of the 44 patients enrolled in the study, 13 (30 %) met our criteria for depression, representing 18 % of patients aged <13 years and 34 % of those aged ≥13 years. Although not reaching statistical significance, the adjusted risk of depression was lower for patients with CKD duration of ≤3 years than for those with longer CKD duration (RR 0.19, 95 % CI 0.02, 1.53), and for those with CKD stage IV (RR 0.23, 95 % CI 0.05, 1.09) and CKD stage V (RR 0.13, 95 % CI 0.01, 1.07) compared to those with CKD stage III. CONCLUSIONS: Our results indicate that depression is common in children with CKD, particularly for those with longstanding renal disease and at CKD stage III.
Authors: Lili Penkower; Mary Amanda Dew; Demetrius Ellis; Susan M Sereika; Julius M M Kitutu; Ron Shapiro Journal: Am J Transplant Date: 2003-11 Impact factor: 8.086
Authors: P Burke; V Meyer; S Kocoshis; D M Orenstein; R Chandra; D J Nord; J Sauer; E Cohen Journal: J Am Acad Child Adolesc Psychiatry Date: 1989-11 Impact factor: 8.829
Authors: Bessie A Young; Michael Von Korff; Susan R Heckbert; Evette J Ludman; Carolyn Rutter; Elizabeth H B Lin; Paul S Ciechanowski; Malia Oliver; Lisa Williams; Jonathan Himmelfarb; Wayne J Katon Journal: Gen Hosp Psychiatry Date: 2010-01-12 Impact factor: 3.238
Authors: A B Ettinger; D M Weisbrot; E E Nolan; K D Gadow; S A Vitale; M R Andriola; N J Lenn; G P Novak; B P Hermann Journal: Epilepsia Date: 1998-06 Impact factor: 5.864
Authors: Anne M Libby; David A Brent; Elaine H Morrato; Heather D Orton; Richard Allen; Robert J Valuck Journal: Am J Psychiatry Date: 2007-06 Impact factor: 18.112
Authors: Na Ri Kang; Yo Han Ahn; Eujin Park; Hyun Jin Choi; Seong Heon Kim; Heeyeon Cho; Min Hyun Cho; Jae Il Shin; Joo Hoon Lee; Young Seo Park; Hae Il Cheong; Hee Gyung Kang; Il-Soo Ha; Young Sook Kwack; Kyoung Hee Han Journal: Pediatr Nephrol Date: 2019-06-20 Impact factor: 3.714
Authors: Andrea Knight; Amy J Kogon; Matthew B Matheson; Bradley A Warady; Susan L Furth; Stephen R Hooper Journal: J Pediatr Date: 2017-07-19 Impact factor: 4.406
Authors: Miguel Verbitsky; Amy J Kogon; Matthew Matheson; Stephen R Hooper; Craig S Wong; Bradley A Warady; Susan L Furth; Ali G Gharavi Journal: J Am Soc Nephrol Date: 2017-03-27 Impact factor: 10.121
Authors: Amy J Kogon; Ji Young Kim; Nina Laney; Jerilynn Radcliffe; Stephen R Hooper; Susan L Furth; Erum A Hartung Journal: Pediatr Nephrol Date: 2019-05-02 Impact factor: 3.714
Authors: Helene Werner; Kathrin Buder; Markus A Landolt; Thomas J Neuhaus; Guido F Laube; Giuseppina Spartà Journal: Pediatr Nephrol Date: 2016-12-23 Impact factor: 3.714