| Literature DB >> 23698095 |
Terunao Takahara1, Tatsuya Maeda.
Abstract
The target of rapamycin (TOR) is an evolutionarily conserved protein kinase that regulates cell growth in response to various environmental as well as intracellular cues through the formation of 2 distinct TOR complexes (TORC), TORC1 and TORC2. Dysregulation of TORC1 and TORC2 activity is closely associated with various diseases, including diabetes, cancer and neurodegenerative disorders. Over the past few years, new regulatory mechanisms of TORC1 and TORC2 activity have been elucidated. Furthermore, recent advances in the study of TOR inhibitors have revealed previously unrecognized cellular functions of TORC1. In this review, we briefly summarize the current understanding of the evolutionarily conserved TOR signalling from upstream regulators to downstream events.Entities:
Keywords: TOR complex; amino acid; cell growth; stress granule; target of rapamycin
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Year: 2013 PMID： 23698095 DOI： 10.1093/jb/mvt047
Source DB: PubMed Journal: J Biochem ISSN： 0021-924X Impact factor: 3.387