AIMS: The molecular mechanisms of the tumorigenesis and recurrence of cervical cancer are poorly understood. The objective of this study was to analyze the expression of phosphorylated c-Src (phospho-c-Src) and its clinical significance in human cervical cancer. METHODS: The expression of phospho-c-Src was determined by immunohistochemistry in a total of 127 cervical specimens including 20 normal cervix tissues, 20 cases of carcinoma in situ of cervix (CIS), and 87 cases of cervical squamous cell carcinoma (CSCC). RESULTS: The expression of phospho-Src in normal cervix, CIS, and CSCC increased gradually in ascending order (p=0.026). In addition, the expression of phospho-Src was correlated with overall (p=0.037) and recurrence (p=0.001) survival of cervical cancer. In multivariate Cox regression analysis, phospho-Src expression was an independent prognosis factor for recurrence-free survival (p=0.004). CONCLUSION: Our present study suggests that Src signaling may play essential role in cervical cancer progression. Phospho-Src expression may be considered as a prognostic marker to predict recurrence in CSCC.
AIMS: The molecular mechanisms of the tumorigenesis and recurrence of cervical cancer are poorly understood. The objective of this study was to analyze the expression of phosphorylated c-Src (phospho-c-Src) and its clinical significance in human cervical cancer. METHODS: The expression of phospho-c-Src was determined by immunohistochemistry in a total of 127 cervical specimens including 20 normal cervix tissues, 20 cases of carcinoma in situ of cervix (CIS), and 87 cases of cervical squamous cell carcinoma (CSCC). RESULTS: The expression of phospho-Src in normal cervix, CIS, and CSCC increased gradually in ascending order (p=0.026). In addition, the expression of phospho-Src was correlated with overall (p=0.037) and recurrence (p=0.001) survival of cervical cancer. In multivariate Cox regression analysis, phospho-Src expression was an independent prognosis factor for recurrence-free survival (p=0.004). CONCLUSION: Our present study suggests that Src signaling may play essential role in cervical cancer progression. Phospho-Src expression may be considered as a prognostic marker to predict recurrence in CSCC.
Authors: M P Lutz; I B Esser; B B Flossmann-Kast; R Vogelmann; H Lührs; H Friess; M W Büchler; G Adler Journal: Biochem Biophys Res Commun Date: 1998-02-13 Impact factor: 3.575
Authors: S Poolkerd; S Leelahakorn; S Manusirivithaya; S Tangjitgamol; T Thavaramara; P Sukwattana; K Pataradule Journal: J Med Assoc Thai Date: 2006-03
Authors: Felix Rühlmann; Manuel Nietert; Thilo Sprenger; Hendrik A Wolff; Kia Homayounfar; Peter Middel; Hanibal Bohnenberger; Tim Beissbarth; B Michael Ghadimi; Torsten Liersch; Lena-Christin Conradi Journal: J Cancer Date: 2017-04-10 Impact factor: 4.207