OBJECTIVE: To determine the effect of glucocorticoids on lipid profile, endothelial function and arterial wall mechanics in children. METHODS: Thirty patients who had received glucocorticoids for 4 to 8 wk were compared with 30 age and sex matched healthy controls. Baseline evaluation included weight, height, body mass index (BMI), blood pressure (BP), lipid profile and Ultrasonographic evaluation of brachial artery for endothelial dependant as well as endothelial independent vasodilatation and evaluation of common carotid artery for intima media thickness (IMT) and arterial wall mechanics. All of these parameters were evaluated two more times- after 4 wk of steroid therapy and 2 wk after stopping the drug. RESULTS: Patients were found to have significant increase in BMI; systolic and diastolic BP; total and LDL cholesterol and carotid IMT and also a decrease in cross sectional compliance (CSC) after 4 wk of steroid therapy (oral prednisolone). However, all these parameters returned towards baseline, 2 wk after stopping the drug. No endothelial dysfunction was observed in these patients. CONCLUSIONS: Four to eight wk of glucocorticoids use in children leads to reversible changes in BMI, systolic and diastolic BP, total and LDL cholesterol, carotid IMT and CSC.
OBJECTIVE: To determine the effect of glucocorticoids on lipid profile, endothelial function and arterial wall mechanics in children. METHODS: Thirty patients who had received glucocorticoids for 4 to 8 wk were compared with 30 age and sex matched healthy controls. Baseline evaluation included weight, height, body mass index (BMI), blood pressure (BP), lipid profile and Ultrasonographic evaluation of brachial artery for endothelial dependant as well as endothelial independent vasodilatation and evaluation of common carotid artery for intima media thickness (IMT) and arterial wall mechanics. All of these parameters were evaluated two more times- after 4 wk of steroid therapy and 2 wk after stopping the drug. RESULTS:Patients were found to have significant increase in BMI; systolic and diastolic BP; total and LDL cholesterol and carotid IMT and also a decrease in cross sectional compliance (CSC) after 4 wk of steroid therapy (oral prednisolone). However, all these parameters returned towards baseline, 2 wk after stopping the drug. No endothelial dysfunction was observed in these patients. CONCLUSIONS: Four to eight wk of glucocorticoids use in children leads to reversible changes in BMI, systolic and diastolic BP, total and LDL cholesterol, carotid IMT and CSC.
Authors: Y Aggoun; D Bonnet; D Sidi; J P Girardet; E Brucker; M Polak; M E Safar; B I Levy Journal: Arterioscler Thromb Vasc Biol Date: 2000-09 Impact factor: 8.311
Authors: D S Celermajer; K E Sorensen; V M Gooch; D J Spiegelhalter; O I Miller; I D Sullivan; J K Lloyd; J E Deanfield Journal: Lancet Date: 1992-11-07 Impact factor: 79.321
Authors: Avni H Thakore; Chao-Yu Guo; Martin G Larson; Diane Corey; Thomas J Wang; Ramachandran S Vasan; Ralph B D'Agostino; Izabella Lipinska; John F Keaney; Emelia J Benjamin; Christopher J O'Donnell Journal: Am J Cardiol Date: 2007-04-18 Impact factor: 2.778
Authors: João Eliakim Dos S Araujo; Rodrigo Miguel-Dos-Santos; Fabrício N Macedo; Patrícia S Cunha; Milene Tavares Fontes; Gilson Masahiro Murata; Sandra Lauton-Santos; Valter J Santana-Filho; Ana Mara de O Silva; Angelo Roberto Antoniolli; Rui Curi; Jullyana de S S Quintans; Rosana de S S Barreto; Marcio R V Santos; Lucindo J Quintans-Junior; André S Barreto Journal: PLoS One Date: 2020-03-18 Impact factor: 3.240