| Literature DB >> 23696056 |
Deepak H Veeregowda1, Anke Kolbe, Henny C van der Mei, Henk J Busscher, Andreas Herrmann, Prashant K Sharma.
Abstract
Recombinant supercharged polypeptides (SUPs) with low cytotoxicity are developed and applied to rejuvenate the lubrication of naturally occurring salivary conditioning films (SCFs). SUPs with 72 positive charges adsorbed and rigidified the SCFs and recruited mucins to form a hydrated layer. These SCFs with SUPs have higher mechanical strength and sustain lubricating effect for longer duration compared with only SCFs.Entities:
Keywords: biolubrication; protein therapeutics; scanning force microscopy; sjögren's syndrome; supercharged polypeptides
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Year: 2013 PMID： 23696056 DOI： 10.1002/adma.201300188
Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849