| Literature DB >> 23694795 |
Jun Eun Park1, Il Joong Park, Young Ae Lim, Wee Gyo Lee, Sung Ran Cho.
Abstract
Blasts showing hemophagocytosis have been very rarely reported in acute lymphoblastic leukemia. We report a pediatric case of B lymphoblastic leukemia (BLL) with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1) showing erythrophagocytosis and thrombophagocytosis by leukemic blasts. About 4% of the leukemic blasts in marrow aspirate smears showed phagocytosis of erythrocytes, platelets, or nuclear remnants in a 3-year-old Korean boy with a diagnosis of BLL. Conventional cytogenetics and molecular analysis revealed the presence of t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1). The patient responded well to chemotherapy and is in a state of complete remission.Entities:
Keywords: aberration; acute lymphoblastic leukemia; cell phagocytosis; childhood ALL; chromosomal; gene rearrangement
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Year: 2013 PMID： 23694795
Source DB: PubMed Journal: Ann Clin Lab Sci ISSN： 0091-7370 Impact factor: 1.256