BACKGROUND: The primary role of inhibin B is the regulation of gametogenesis via negative feedback on the production of follicle stimulating hormone (FSH) by the pituitary. METHODS: We studied 14 males with primary hypothyroidism due to various etiologies to determine if they exhibited hypogonadotrophic hypogonadism involving the reproductive segment of the gonadotrophic axis. Levels of inhibin B, FSH, luteinizing hormone, testosterone, free thyroxine, and thyrotropin were measured. RESULTS: The mean level of inhibin B in males with primary hypothyroidism was found to be approximately half that of normal males. The FSH level remained within the normal range and no reciprocal increase was observed as occurs in other conditions with reduced inhibin B. CONCLUSIONS: Our results indicate that primary hypothyroidism has a significant effect on inhibin B levels without reciprocal increase in FSH, which is consistent with a hypogonadotrophic hypogonadal state affecting the reproductive segment of the gonadotrophic axis.
BACKGROUND: The primary role of inhibin B is the regulation of gametogenesis via negative feedback on the production of follicle stimulating hormone (FSH) by the pituitary. METHODS: We studied 14 males with primary hypothyroidism due to various etiologies to determine if they exhibited hypogonadotrophic hypogonadism involving the reproductive segment of the gonadotrophic axis. Levels of inhibin B, FSH, luteinizing hormone, testosterone, free thyroxine, and thyrotropin were measured. RESULTS: The mean level of inhibin B in males with primary hypothyroidism was found to be approximately half that of normal males. The FSH level remained within the normal range and no reciprocal increase was observed as occurs in other conditions with reduced inhibin B. CONCLUSIONS: Our results indicate that primary hypothyroidism has a significant effect on inhibin B levels without reciprocal increase in FSH, which is consistent with a hypogonadotrophic hypogonadal state affecting the reproductive segment of the gonadotrophic axis.
Authors: B D Anawalt; R A Bebb; A M Matsumoto; N P Groome; P J Illingworth; A S McNeilly; W J Bremner Journal: J Clin Endocrinol Metab Date: 1996-09 Impact factor: 5.958
Authors: Marcin Gołyński; Piotr Dębiak; Magdalena Gołyńska; Ewa Myśliwiec; Piotr Szkodziak; Grzegorz Kalisz; Anna Śmiech; Krzysztof Lutnicki; Marcin Szczepanik Journal: J Vet Res Date: 2018-12-10 Impact factor: 1.744
Authors: Marcin Gołyński; Michał Metyk; Piotr Szkodziak; Krzysztof Lutnicki; Grzegorz Kalisz; Marcin Szczepanik; Piotr Wilkołek; Piotr Dobrowolski Journal: J Vet Res Date: 2019-03-22 Impact factor: 1.744