| Literature DB >> 236908 |
T J Ruigrok, F J Burgersdijk, A N Zimmerman.
Abstract
Perfusion of isolated rat hearts with a Ca-2+-containing medium, after a Ca2+-free perfusion period, results in an irreversible loss of electrical and mechanical activity of the heart, as well as a large release of intracellular components such as lactate dehydrogenase. These phenomena can be evoked, when hearts are perfused at a constant perfusion pressure or at a constant flow rate. Evidence is provided that recovery of the mechanical activity of the heart is not a requisite for lactate dehydrogenase release.Entities:
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Year: 1975 PMID： 236908
Source DB: PubMed Journal: Eur J Cardiol ISSN： 0301-4711