OBJECTIVE: The objective of this article is to investigate clinical presentations and outcomes of systemic lupus erythematosus (SLE) patients with infection admitted to the intensive care unit (ICU). METHODS: SLE patients with infection, SLE patients with noninfectious causes, and non-SLE patients with infection were identified from the Cooper University Hospital Project IMPACT database between 2002 and 2010. We examined demographic data, APACHE II scores, physiologic data, laboratory data, length of stay in the ICU and hospital, and mortality of the three groups. RESULTS: Twenty-five SLE patients with infection, 45 SLE patients with noninfectious causes, and 1466 non-SLE patients with infection were included in the study. SLE patients with infection had higher APACHE II scores, higher maximum temperature, higher minimum and maximum heart rate (HR), lower minimum and maximum systolic blood pressure (SBP), and longer ICU length of stay in comparison to SLE patients with noninfectious causes. There were no statistical differences in white blood cell (WBC) count. SLE patients with infection had a higher mortality compared to SLE patients with noninfectious causes. There was no difference in mortality between SLE patients with infection and non-SLE patients with infection. CONCLUSION: SLE patients with infection in the ICU had a higher mortality and a higher APACHE II score compared to SLE patients with noninfectious causes in the ICU. Their physiologic signs including temperature, HR, and SBP were more reflective of infection than their WBC count.
OBJECTIVE: The objective of this article is to investigate clinical presentations and outcomes of systemic lupus erythematosus (SLE) patients with infection admitted to the intensive care unit (ICU). METHODS:SLEpatients with infection, SLEpatients with noninfectious causes, and non-SLEpatients with infection were identified from the Cooper University Hospital Project IMPACT database between 2002 and 2010. We examined demographic data, APACHE II scores, physiologic data, laboratory data, length of stay in the ICU and hospital, and mortality of the three groups. RESULTS: Twenty-five SLEpatients with infection, 45 SLEpatients with noninfectious causes, and 1466 non-SLEpatients with infection were included in the study. SLEpatients with infection had higher APACHE II scores, higher maximum temperature, higher minimum and maximum heart rate (HR), lower minimum and maximum systolic blood pressure (SBP), and longer ICU length of stay in comparison to SLEpatients with noninfectious causes. There were no statistical differences in white blood cell (WBC) count. SLEpatients with infection had a higher mortality compared to SLEpatients with noninfectious causes. There was no difference in mortality between SLEpatients with infection and non-SLEpatients with infection. CONCLUSION:SLEpatients with infection in the ICU had a higher mortality and a higher APACHE II score compared to SLEpatients with noninfectious causes in the ICU. Their physiologic signs including temperature, HR, and SBP were more reflective of infection than their WBC count.
Authors: Paul Chabert; William Danjou; Mehdi Mezidi; Julien Berthiller; Audrey Bestion; Abla-Akpene Fred; Claude Guerin; Laurent Argaud; Vincent Piriou; Eric Bonnefoy-Cudraz; Jean-Jacques Lehot; Jean-Luc Fellahi; Thomas Rimmele; Frederic Aubrun; Jean-Christophe Richard; Laure Gallay; Arnaud Hot Journal: Medicine (Baltimore) Date: 2021-09-03 Impact factor: 1.817