Literature DB >> 23690040

Prelog and anti-Prelog stereoselectivity of two ketoreductases from Candida glabrata.

Ping Liang1, Bin Qin, Mao Mu, Xin Zhang, Xian Jia, Song You.   

Abstract

Two ketoreductases from Candida glabrata were used for the asymmetric reduction of prochiral substituted acetophenones displayed different enantiopreference toward para-, meta-substituted and ortho-halogen substituted acetophenones with excellent enantioselectivity. Homology modeling and docking analysis were in conformity with this interested enantiopreference obtained from experimental tests. The reduction of a series of other substituted aryl ketones was also investigated using the two ketoreductases.

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Year:  2013        PMID： 23690040     DOI： 10.1007/s10529-013-1228-0

Source DB:  PubMed          Journal:  Biotechnol Lett        ISSN： 0141-5492            Impact factor:   2.461


  3 in total

1.  A novel carbonyl reductase with anti-Prelog stereospecificity for the production of t-butyl 6-cyano-(3R, 5R)-dihydroxyhexanoate.

Authors:  Qingchao Jin; Zhige Wu; Yanping Dou; Yu Yang; Jingjing Xia; Zhihua Jin
Journal:  3 Biotech       Date:  2019-05-02       Impact factor: 2.406

2.  Enantioselectivity and Enzyme-Substrate Docking Studies of a Ketoreductase from Sporobolomyces salmonicolor (SSCR) and Saccharomyces cerevisiae (YOL151w).

Authors:  Phung-Hoang Nguyen; Maya West; Brent D Feske; Clifford W Padgett
Journal:  Int Sch Res Notices       Date:  2014-08-17

3.  A strategy to identify a ketoreductase that preferentially synthesizes pharmaceutically relevant (S)-alcohols using whole-cell biotransformation.

Authors:  Saiful F Haq; Anirudh P Shanbhag; Subbulakshmi Karthikeyan; Imran Hassan; Kannan Thanukrishnan; Abhishek Ashok; Sunilkumar Sukumaran; S Ramaswamy; Nagakumar Bharatham; Santanu Datta; Shalaka Samant; Nainesh Katagihallimath
Journal:  Microb Cell Fact       Date:  2018-12-03       Impact factor: 5.328
  3 in total

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