Literature DB >> 23687365

Extrapulmonary disseminated tuberculosis with tuberculous adrenalitis: a stitch in time saves nine.

Chandrasekharan Rajasekharan1, Sivasankarannair Ajithkumar, Varghese Anto, Rajasekharan Parvathy.   

Abstract

A 40-year-old manual labourer presented with easy fatiguability, recurrent vomiting and loss of weight of 3 months, duration. Upon examination, there was significant axillary and cervical lymphadenopathy. No pallor, icterus or clubbing was evident. There was generalised hyperpigmentation and multiple oral ulcers. The blood pressure 90/60 mm Hg in the right upper limb in the supine position. Investigations showed a low serum cortisol. Mantoux test was strongly positive (20 mm).A fine needle aspiration biopsy of the cervical lymph node revealed reactive changes. Bone marrow aspiration and biopsy were normal. Cervical lymph node biopsy showed caseating granulomas suggestive of tuberculous lymphadenitis. A CT scan of the abdomen showed bilaterally enlarged adrenal glands with hypodense areas suggestive of necrosis. He was diagnosed with extrapulmonary disseminated tuberculosis with tuberculous adrenalitis. He was started on directly observed therapy (DOTS) for disseminated tuberculosis and 40 mg of prednisolone. He is improving with treatment.

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Mesh:

Year:  2013        PMID: 23687365      PMCID: PMC3669826          DOI: 10.1136/bcr-2012-008011

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  6 in total

Review 1.  The endocrinology of adrenal tuberculosis: the effects of tuberculosis on the hypothalamo-pituitary-adrenal axis and adrenocortical function.

Authors:  F Kelestimur
Journal:  J Endocrinol Invest       Date:  2004-04       Impact factor: 4.256

2.  Addison's disease due to adrenal tuberculosis: contrast-enhanced CT features and clinical duration correlation.

Authors:  Ying-Kun Guo; Zhi-Gang Yang; Yuan Li; En-Sen Ma; Yu-Ping Deng; Peng-Qiu Min; Long-Lin Yin; Jian Hu; Xiao-Chun Zhang; Tian-Wu Chen
Journal:  Eur J Radiol       Date:  2006-12-19       Impact factor: 3.528

Review 3.  Adrenal insufficiency.

Authors:  W Oelkers
Journal:  N Engl J Med       Date:  1996-10-17       Impact factor: 91.245

4.  CT findings of adrenal glands in patients with tuberculous Addison's disease.

Authors:  Y X Wang; C R Chen; G X He; A R Tang
Journal:  J Belge Radiol       Date:  1998-10

5.  A critical examination of adrenal tuberculosis and a 28-year autopsy experience of active tuberculosis.

Authors:  K Y Lam; C Y Lo
Journal:  Clin Endocrinol (Oxf)       Date:  2001-05       Impact factor: 3.478

Review 6.  New vision for Revised National Tuberculosis Control Programme (RNTCP): Universal access - "reaching the un-reached".

Authors:  Kuldeep Singh Sachdeva; Ashok Kumar; Puneet Dewan; Ajay Kumar; Srinath Satyanarayana
Journal:  Indian J Med Res       Date:  2012-05       Impact factor: 2.375

  6 in total

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