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Literature DB >> 23686723

Platinum(IV) prodrugs with haloacetato ligands in the axial positions can undergo hydrolysis under biologically relevant conditions.

Ezequiel Wexselblatt¹, Eylon Yavin, Dan Gibson.

Abstract

Losing ligands rapidly: Pt(IV) complexes with haloacetato ligands can hydrolyze rapidly under biological conditions (pH 7 and 37 °C, see scheme) and the rate increases with increasing pH value. Possible mechanisms for this hydrolysis are examined using H2(18)O and ESI-MS analysis.

Entities: Chemical

Mesh：

Substances：

Year: 2013 PMID： 23686723 DOI： 10.1002/anie.201300640

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

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