PURPOSE: We investigated prospectively the relationship between dietary intakes of methionine and B vitamins associated with one-carbon metabolism and breast cancer risk, including modification by age, hormone receptor status and alcohol consumption. Interactions between different B vitamins and methionine were also examined. METHODS: During follow-up of 20,756 women from the Melbourne Collaborative Cohort Study for an average of 16 years, we ascertained 936 incident breast cancers. Dietary intakes were estimated using a 121-item food frequency questionnaire. Hazard ratios (HR) and 95 % confidence intervals were estimated using Cox regression. RESULTS: We found weak evidence for an inverse association between breast cancer risk and riboflavin intake (fourth versus first quartile, HR Q4 vs. Q1 = 0.84 (0.69, 1.01); p linear trend = 0.05) and a positive association for vitamin B12 (HR Q4 vs. Q1 = 1.21 (1.00, 1.46); p linear trend = 0.06). We did not find any significant interactions between alcohol consumption and any of the B vitamins or methionine intake (all p interaction > 0.17) or between methionine or folate intake and any other B vitamins (all p interaction > 0.07). No association varied by tumor hormone receptor status (all p homogeneity > 0.14). CONCLUSIONS: We found weak evidence of an inverse association between breast cancer risk and riboflavin intake and a positive association with vitamin B12.
PURPOSE: We investigated prospectively the relationship between dietary intakes of methionine and B vitamins associated with one-carbon metabolism and breast cancer risk, including modification by age, hormone receptor status and alcohol consumption. Interactions between different B vitamins and methionine were also examined. METHODS: During follow-up of 20,756 women from the Melbourne Collaborative Cohort Study for an average of 16 years, we ascertained 936 incident breast cancers. Dietary intakes were estimated using a 121-item food frequency questionnaire. Hazard ratios (HR) and 95 % confidence intervals were estimated using Cox regression. RESULTS: We found weak evidence for an inverse association between breast cancer risk and riboflavin intake (fourth versus first quartile, HR Q4 vs. Q1 = 0.84 (0.69, 1.01); p linear trend = 0.05) and a positive association for vitamin B12 (HR Q4 vs. Q1 = 1.21 (1.00, 1.46); p linear trend = 0.06). We did not find any significant interactions between alcohol consumption and any of the B vitamins or methionine intake (all p interaction > 0.17) or between methionine or folate intake and any other B vitamins (all p interaction > 0.07). No association varied by tumorhormone receptor status (all p homogeneity > 0.14). CONCLUSIONS: We found weak evidence of an inverse association between breast cancer risk and riboflavin intake and a positive association with vitamin B12.
Authors: Roni T Falk; Paige Maas; Catherine Schairer; Nilanjan Chatterjee; Jerome E Mabie; Christopher Cunningham; Saundra S Buys; Claudine Isaacs; Regina G Ziegler Journal: Am J Epidemiol Date: 2014-08-22 Impact factor: 4.897
Authors: Tiffany A Katz; Serena G Liao; Vincent J Palmieri; Robert K Dearth; Thushangi N Pathiraja; Zhiguang Huo; Patricia Shaw; Sarah Small; Nancy E Davidson; David G Peters; George C Tseng; Steffi Oesterreich; Adrian V Lee Journal: Cancer Prev Res (Phila) Date: 2015-08-19
Authors: Y M Geurts; P-A Dugué; J E Joo; E Makalic; C-H Jung; W Guan; S Nguyen; M L Grove; E M Wong; A M Hodge; J K Bassett; L M FitzGerald; H Tsimiklis; L Baglietto; G Severi; D F Schmidt; D D Buchanan; R J MacInnis; J L Hopper; J S Pankow; E W Demerath; M C Southey; G G Giles; D R English; R L Milne Journal: Int J Obes (Lond) Date: 2017-10-16 Impact factor: 5.095
Authors: Heleen Van Puyvelde; Nikos Papadimitriou; Joanna Clasen; David Muller; Carine Biessy; Pietro Ferrari; Jytte Halkjær; Kim Overvad; Anne Tjønneland; Renée T Fortner; Verena Katzke; Matthias B Schulze; Paolo Chiodini; Giovanna Masala; Valeria Pala; Carlotta Sacerdote; Rosario Tumino; Marije F Bakker; Antonio Agudo; Eva Ardanaz; María Dolores Chirlaque López; Maria-Jose Sánchez; Ulrika Ericson; Björn Gylling; Therese Karlsson; Jonas Manjer; Julie A Schmidt; Geneviève Nicolas; Corinne Casagrande; Elisabete Weiderpass; Alicia K Heath; Lode Godderis; Koen Van Herck; Dirk De Bacquer; Marc J Gunter; Inge Huybrechts Journal: Nutrients Date: 2021-05-28 Impact factor: 5.717