| Literature DB >> 23686009 |
Xinhui Wang1, Guoqing Gong2, Wenhui Yang1, Yunzhan Li1, Meiling Jiang1, Linlin Li1.
Abstract
This study aimed to investigate the effects of galangin on liver fibrosis in rats induced by subcutaneous injection of carbon tetrachloride (CCl4). The administration of CCl4 to rats for 12 weeks caused significant increase of hyaluronic acid, laminin, alanine transaminase, aspartate transaminase and decrease of total protein, albumin in serum, while the influences could be reversed by galangin. Galangin markedly reduced hepatic malondialdehyde, hydroxyproline concentration, increased activities of liver superoxide dismutase, glutathione peroxidase compared with CCl4-treated rats. Histological results indicated that galangin alleviated liver damage. In addition, treatment with galangin significantly down-regulated expressions of α-smooth muscle actin and transforming growth factor β1. These results suggest galangin can inhibit liver fibrosis induced by CCl4 in rats, which was probably associated with its effect on removing oxygen free radicals, decreasing lipid peroxidation, as well as inhibiting hepatic stellate cells activation and proliferation.Entities:
Keywords: ALB; ALT; AST; CCl(4); CMC-Na; ECM; GSH-Px; HA; HI; HSCs; Hyp; LN; MDA; ROS; SOD; TGF-β1; TP; alanine transaminase; albumin; aspartate transaminase; carbon tetrachloride; carboxymethyl cellulose-Na; extracellular matrix; glutathione peroxidase; hepatic index; hepatic stellate cells; hyaluronic acid; hydroxyproline; laminin; malondialdehyde; reactive oxygen species; superoxide dismutase; total protein; transforming growth factor β1; α-SMA; α-smooth muscle actin
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Year: 2013 PMID： 23686009 DOI： 10.1016/j.etap.2013.04.004
Source DB: PubMed Journal: Environ Toxicol Pharmacol ISSN： 1382-6689 Impact factor: 4.860