| Literature DB >> 23685259 |
Jesse G Toe1, Marc Pellegrini, Tak Wah Mak.
Abstract
The continued global burden wrought by chronic infectious disease is unrelenting. Current therapies have curbed the severity of disease for patients, but Human Immunodeficiency Virus (HIV) and Hepatitis B (HBV) infection remain incurable and Mycobacterium tuberculosis (MTB) is rapidly becoming resistant to our existing antibiotics. Much attention has been given to enhancing T cell immunity through the use of certain common gamma-chain cytokines, which have proven to be essential and necessary for T cell survival and function. This article reviews the pre-clinical and clinical literature surrounding IL-2, IL-7, IL-15 and IL-21 and we comment on the potential therapeutic promise of these cytokines as adjuvant treatments for chronic infectious diseases.Entities:
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Year: 2013 PMID： 23685259 DOI： 10.1016/j.molimm.2013.04.008
Source DB: PubMed Journal: Mol Immunol ISSN： 0161-5890 Impact factor: 4.407