Adrien Rossary1, Marie-Chantal Farges1, Bruno Lamas1, Elizabeth A Miles2, Paul S Noakes2, Lefkothea-Stella Kremmyda2, Maria Vlachava2, Norma D Diaper3, Sian M Robinson4, Keith M Godfrey4, Philip C Calder3, Marie-Paule Vasson5. 1. Clermont Université, Université d'Auvergne, UMR 1019, Unité de Nutrition Humaine, CRNH-Auvergne, BP 10448, F-63000 Clermont-Ferrand, France. 2. Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. 3. Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; Southampton NIHR Nutrition, Diet & Lifestyle Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom. 4. Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; Southampton NIHR Nutrition, Diet & Lifestyle Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom; The Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom. 5. Clermont Université, Université d'Auvergne, UMR 1019, Unité de Nutrition Humaine, CRNH-Auvergne, BP 10448, F-63000 Clermont-Ferrand, France; CHU Clermont-Ferrand, Centre Jean Perrin, Unité de Nutrition, CLARA, F-63000 Clermont-Ferrand, France. Electronic address: m-paule.vasson@u-clermont1.fr.
Abstract
BACKGROUND & AIMS: Oily fish is a good source of n-3 long-chain polyunsaturated fatty acids. Since these fatty acids may change efficiency of amino acid (AA) absorption, we determined whether increased salmon consumption influences plasma AA concentrations in pregnant women and their newborns. METHODS: Pregnant women were randomly allocated to remain on their habitual diet (n = 61; control group) or to consume two 150 g farmed salmon portions per week from 20 weeks pregnancy until birth (n = 62; salmon group). Plasma AA concentrations were determined in women at w20, w34 and w38 of pregnancy and in umbilical cord at delivery. RESULTS: Concentrations of arginine, valine, leucine and lysine were affected by both time of pregnancy and salmon intake (p < 0.05), with a smaller gestation-associated decrease in the salmon group. Total essential AA concentrations were similar in both groups at w20, but at w38 were higher in salmon group (p < 0.05). Cord plasma AA concentrations, higher than in maternal plasma (p < 0.01), were similar in the two groups (p > 0.05). CONCLUSIONS: Two portions/wk of oily fish increased plasma essential AA concentrations during pregnancy and could contribute to a maternal health benefit. Two portions/wk of salmon did not affect plasma AA concentrations in the newborn. CLINICAL TRIALS IDENTIFIER: NCT00801502.
BACKGROUND & AIMS: Oily fish is a good source of n-3 long-chain polyunsaturated fatty acids. Since these fatty acids may change efficiency of amino acid (AA) absorption, we determined whether increased salmon consumption influences plasma AA concentrations in pregnant women and their newborns. METHODS: Pregnant women were randomly allocated to remain on their habitual diet (n = 61; control group) or to consume two 150 g farmed salmon portions per week from 20 weeks pregnancy until birth (n = 62; salmon group). Plasma AA concentrations were determined in women at w20, w34 and w38 of pregnancy and in umbilical cord at delivery. RESULTS: Concentrations of arginine, valine, leucine and lysine were affected by both time of pregnancy and salmon intake (p < 0.05), with a smaller gestation-associated decrease in the salmon group. Total essential AA concentrations were similar in both groups at w20, but at w38 were higher in salmon group (p < 0.05). Cord plasma AA concentrations, higher than in maternal plasma (p < 0.01), were similar in the two groups (p > 0.05). CONCLUSIONS: Two portions/wk of oily fish increased plasma essential AA concentrations during pregnancy and could contribute to a maternal health benefit. Two portions/wk of salmon did not affect plasma AA concentrations in the newborn. CLINICAL TRIALS IDENTIFIER: NCT00801502.
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