| Literature DB >> 23683404 |
Dariusz Grzanka1, Maciej Gagat, Magdalena Izdebska.
Abstract
Actin is one of the most abundant cytoskeletal proteins, which takes part in many cellular processes. This review provides information on the history, forms and localization of actin and its role, in particular in cellular death processes. We discuss the relationships between reorganization of actin filaments and apoptosis, mitotic catastrophe and differentiation. Finally, we discuss the translocation and accumulation of actin in the nuclear area. Moreover, owing to the difficulties of F-actin localization by transmission electron microscopy (TEM), the phalloidin-based method of its detection using streptavidin-coated quantum dots is presented in this review.Keywords: Actin; Cell death; F-actin; Nuclear actin
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Year: 2013 PMID: 23683404 DOI: 10.1016/j.acthis.2013.04.002
Source DB: PubMed Journal: Acta Histochem ISSN: 0065-1281 Impact factor: 2.479