Copper-catalyzed synthesis of trifluoromethyl-substituted isoxazolines.

A mild and efficient copper-catalyzed trifluoromethylation reaction which involves the cyclization of oximes has been developed. This method provides a convenient access to a variety of useful CF3-containing 4,5-dihydroisoxazoles by constructing a C-CF3 bond and a C-O bond in one step.