Literature DB >> 23680444

A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity.

Claudio Battilocchio1, Giovanna Poce, Salvatore Alfonso, Giulio Cesare Porretta, Sara Consalvi, Lidia Sautebin, Simona Pace, Antonietta Rossi, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Silvia Schenone, Antonio Giordani, Luigia Di Francesco, Paola Patrignani, Mariangela Biava.   

Abstract

We report the synthesis and bio-pharmacological evaluation of a class of pyrrole derivatives featuring a small appendage fragment (carbaldehyde, oxime, nitrile) on the central core. Compound 1c proved to be extremely effective in vivo, showing an interesting anti-nociceptic profile that is comparable to reference compounds already marketed, hence representing a great stimulus for a further improvement of this class of molecules.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23680444     DOI： 10.1016/j.bmc.2013.04.031

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  10 in total

1.  A mild and efficient AgSbF6-catalyzed synthesis of fully substituted pyrroles through a sequential propargylation/amination/cycloisomerization reaction.

Authors:  Satheesh Gujarathi; Xingui Liu; Lin Song; Howard Hendrickson; Guangrong Zheng
Journal:  Tetrahedron       Date:  2014-08-26       Impact factor: 2.457

2.  Employing of Fe3O4/CuO/ZnO@MWCNT MNCs in the solvent-free synthesis of new cyanopyrroloazepine derivatives and investigation of biological activity.

Authors:  Neda Zare Davijani; Reza Kia-Kojoori; Shahrzad Abdolmohammadi; Sepehr Sadegh-Samiei
Journal:  Mol Divers       Date:  2021-12-03       Impact factor: 3.364

3.  Effects of a pyrrole-based, microtubule-depolymerizing compound on RAW 264.7 macrophages.

Authors:  John A Ciemniecki; Clarke P Lewis; John T Gupton; Krista Fischer-Stenger
Journal:  Chem Biol Interact       Date:  2016-01-11       Impact factor: 5.192

4.  Effects of a novel microtubule-depolymerizer on pro-inflammatory signaling in RAW264.7 macrophages.

Authors:  Samuel P Gilmore; Anna L K Gonye; Elizabeth C Li; Santiago Espinosa de Los Reyes; John T Gupton; Omar A Quintero; Krista Fischer-Stenger
Journal:  Chem Biol Interact       Date:  2017-12-13       Impact factor: 5.192

Review 5.  Microwave assisted synthesis of five membered nitrogen heterocycles.

Authors:  Gopinadh Meera; K R Rohit; Salim Saranya; Gopinathan Anilkumar
Journal:  RSC Adv       Date:  2020-09-30       Impact factor: 4.036

6.  Novel pyrrolopyrimidine derivatives: design, synthesis, molecular docking, molecular simulations and biological evaluations as antioxidant and anti-inflammatory agents.

Authors:  Amira I Sayed; Yara E Mansour; Mohamed A Ali; Omnia Aly; Zainab M Khoder; Ahmed M Said; Samar S Fatahala; Rania H Abd El-Hameed
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.756

7.  Selective One-Pot Multicomponent Synthesis of N-Substituted 2,3,5-Functionalized 3-Cyanopyrroles via the Reaction between α-Hydroxyketones, Oxoacetonitriles, and Primary Amines.

Authors:  Mengxin Xia; Ziad Moussa; Zaher M A Judeh
Journal:  Molecules       Date:  2022-08-18       Impact factor: 4.927

8.  Design, synthesis, in silico and biological evaluations of novel polysubstituted pyrroles as selective acetylcholinesterase inhibitors against Alzheimer's disease.

Authors:  Hormoz Pourtaher; Alireza Hasaninejad; Aida Iraji
Journal:  Sci Rep       Date:  2022-09-08       Impact factor: 4.996

9.  New Pyrrole Derivatives as Promising Biological Agents: Design, Synthesis, Characterization, In Silico, and Cytotoxicity Evaluation.

Authors:  Beatrice-Cristina Ivan; Stefania-Felicia Barbuceanu; Camelia Mia Hotnog; Adriana Iuliana Anghel; Robert Viorel Ancuceanu; Mirela Antonela Mihaila; Lorelei Irina Brasoveanu; Sergiu Shova; Constantin Draghici; Octavian Tudorel Olaru; George Mihai Nitulescu; Mihaela Dinu; Florea Dumitrascu
Journal:  Int J Mol Sci       Date:  2022-08-09       Impact factor: 6.208

Review 10.  Structure-activity relationships for the synthesis of selective cyclooxygenase 2 inhibitors: an overview (2009-2016).

Authors:  G Carullo; F Galligano; F Aiello
Journal:  Medchemcomm       Date:  2016-12-12       Impact factor: 3.597
  10 in total

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