Mohammad Delwer Hossain Hawlader1, Emiko Noguchi2, Shams El Arifeen3, Lars Åke Persson4, Sophie E Moore5, Rubhana Raqib3, Yukiko Wagatsuma1. 1. 1Department of Clinical Trial and Clinical Epidemiology, Faculty of Medicine,University of Tsukuba,Tsukuba,Japan. 2. 3Department of Medical Genetics, Faculty of Medicine,University of Tsukuba,1-1-1 Tennodai,Tsukuba,Ibaraki 305-8575,Japan. 3. 2International Centre for Diarrhoeal Disease Research,Bangladesh (icddr,b),Dhaka,Bangladesh. 4. 5Department of International Women and Child Health,Uppsala University,Uppsala,Sweden. 5. 6MRC International Nutrition Group,London School of Hygiene & Tropical Medicine,London,UK.
Abstract
OBJECTIVE: To investigate the association between current childhood nutritional status and current wheezing among pre-school children in rural Bangladesh. DESIGN: Cross-sectional study. SETTING: Matlab region, rural Bangladesh. SUBJECTS: Children (n 912) aged 4·5 years. Anthropometric measurements of the mothers and their children were taken during a 1-year period from December 2007 to November 2008. Current wheezing was identified using the International Study of Asthma and Allergies in Childhood questionnaire. Serum total IgE was measured by human IgE quantitative ELISA. IgE specific antibody to dust mites (Dermatophagoides pteronyssinus) was measured by the CAP-FEIA system (Phadia AB, Uppsala, Sweden). RESULTS: Wheezing at 4·5 years old was significantly associated with stunting (OR = 1·58; 95 % CI 1·13, 2·22) and underweight (OR = 1·39; 95 % CI 1·00, 1·94). The association with stunting remained significant after adjustment for sex, birth weight, birth length, gestational age at birth, mother's parity, maternal BMI, family history of asthma, socio-economic status, season of birth and intervention trial arm (OR = 1·74; 95 % CI 1·19, 2·56). CONCLUSIONS: Stunting was a significant risk factor for wheezing among rural Bangladeshi children. Further studies will be required to confirm the relationship between nutritional status and allergic illnesses in developing countries.
OBJECTIVE: To investigate the association between current childhood nutritional status and current wheezing among pre-school children in rural Bangladesh. DESIGN: Cross-sectional study. SETTING: Matlab region, rural Bangladesh. SUBJECTS:Children (n 912) aged 4·5 years. Anthropometric measurements of the mothers and their children were taken during a 1-year period from December 2007 to November 2008. Current wheezing was identified using the International Study of Asthma and Allergies in Childhood questionnaire. Serum total IgE was measured by human IgE quantitative ELISA. IgE specific antibody to dust mites (Dermatophagoides pteronyssinus) was measured by the CAP-FEIA system (Phadia AB, Uppsala, Sweden). RESULTS:Wheezing at 4·5 years old was significantly associated with stunting (OR = 1·58; 95 % CI 1·13, 2·22) and underweight (OR = 1·39; 95 % CI 1·00, 1·94). The association with stunting remained significant after adjustment for sex, birth weight, birth length, gestational age at birth, mother's parity, maternal BMI, family history of asthma, socio-economic status, season of birth and intervention trial arm (OR = 1·74; 95 % CI 1·19, 2·56). CONCLUSIONS: Stunting was a significant risk factor for wheezing among rural Bangladeshi children. Further studies will be required to confirm the relationship between nutritional status and allergic illnesses in developing countries.
Authors: Anda R Gliga; Karin Engström; Maria Kippler; Helena Skröder; Sultan Ahmed; Marie Vahter; Rubhana Raqib; Karin Broberg Journal: Arch Toxicol Date: 2018-06-08 Impact factor: 5.153