| Literature DB >> 23678959 |
Ruja Shrestha1, Paramita Mukherjee, Yichen Tan, Zachary C Litman, John F Hartwig.
Abstract
We report the Pd-catalyzed amination of arenes to form N-aryl phthalimides with regioselectivity controlled predominantly by steric effects. Mono-, di-, and trisubstituted arenes lacking a directing group undergo amination reactions with moderate to high yields and high regioselectivities from sequential addition of PhI(OAc)2 as an oxidant in the presence of Pd(OAc)2 as catalyst. This sterically derived selectivity contrasts that for analogous arene acetoxylation.Entities:
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Year: 2013 PMID： 23678959 DOI： 10.1021/ja4032677
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419