Gwan Gyu Song1, Jae-Hoon Kim1, Young Ho Lee2. 1. Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Korea. 2. Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Korea lyhcgh@korea.ac.kr.
Abstract
INTRODUCTION: The purpose of this study was to examine whether the insertion (I) or deletion (D) of angiotensin-converting enzyme (ACE) polymorphism confers susceptibility to sarcoidosis. METHODS: A meta-analysis on the associations between the ACE I/D polymorphism and sarcoidosis was conducted. RESULTS: Seventeen comparison studies consisting of 1556 cases and 2381 controls were available for the meta-analysis. Meta-analysis revealed a significant association between the D allele and sarcoidosis (OR 1.206, 95% CI 1.049-1.386, p = 0.009). An ethnicity-specific meta-analysis of the DD+ID genotype showed an association with sarcoidosis in East Asians (OR 1.342, 95% CI 1.041-1.729, p = 0.023). An association was found between the DD genotype of the ACE I/D polymorphism and sarcoidosis (OR 1.251, 95% CI 1.070-1.463, p = 0.005). Furthermore, stratification by ethnicity indicated an association between the DD genotype and sarcoidosis in Europeans (OR = 1.215, 95% CI = 1.010-1.462, p = 0.039). CONCLUSIONS: Our meta-analysis demonstrates that the ACE I/D polymorphism is associated with susceptibility to sarcoidosis in European and East Asian populations.
INTRODUCTION: The purpose of this study was to examine whether the insertion (I) or deletion (D) of angiotensin-converting enzyme (ACE) polymorphism confers susceptibility to sarcoidosis. METHODS: A meta-analysis on the associations between the ACE I/D polymorphism and sarcoidosis was conducted. RESULTS: Seventeen comparison studies consisting of 1556 cases and 2381 controls were available for the meta-analysis. Meta-analysis revealed a significant association between the D allele and sarcoidosis (OR 1.206, 95% CI 1.049-1.386, p = 0.009). An ethnicity-specific meta-analysis of the DD+ID genotype showed an association with sarcoidosis in East Asians (OR 1.342, 95% CI 1.041-1.729, p = 0.023). An association was found between the DD genotype of the ACE I/D polymorphism and sarcoidosis (OR 1.251, 95% CI 1.070-1.463, p = 0.005). Furthermore, stratification by ethnicity indicated an association between the DD genotype and sarcoidosis in Europeans (OR = 1.215, 95% CI = 1.010-1.462, p = 0.039). CONCLUSIONS: Our meta-analysis demonstrates that the ACE I/D polymorphism is associated with susceptibility to sarcoidosis in European and East Asian populations.
Authors: Robert Kieszko; Paweł Krawczyk; Tomasz Powrózek; Aneta Szudy-Szczyrek; Michał Szczyrek; Iwona Homa; Jadwiga Daniluk; Janusz Milanowski Journal: Arch Med Sci Date: 2015-04-28 Impact factor: 3.318