OBJECTIVES: To estimate the prevalence of infection with Mycobacterium tuberculosis and the annual risk of tuberculous infection (ARTI) and to compare this with the prevalence of tuberculosis (TB) over study clusters and households. METHODS: A nationwide, stratified cluster sample survey was carried out in 2006-2007 in Viet Nam to assess the prevalence of infection with M. tuberculosis. A representative sample of children aged 6-14 years underwent a tuberculin skin test (TST) using the Mantoux method. RESULTS: Of 23,160 children registered, 21,487 (92.8%) were tested and read and available for analysis. Using a cut-off point of 10 mm, the estimated prevalence of TST positivity was 16.7%, and the ARTI was 1.7% (95%CI 1.5-1.8). Higher infection rates were found in urban than in rural and remote areas, and infection rates increased with age. There was significant association between the prevalence of TB disease and infection at the cluster level (regression coefficient 0.54, 95%CI 0.06-1.01, P = 0.027, correlation coefficient R(2) 0.120). Children with a (recent) case of TB in the household were 1.6 times more likely to be TST-positive than children in households with no recent cases (P < 0.05). CONCLUSION: The estimated nationwide ARTI was 1.7%. TST positivity was associated with the presence of a TB case in the household.
OBJECTIVES: To estimate the prevalence of infection with Mycobacterium tuberculosis and the annual risk of tuberculous infection (ARTI) and to compare this with the prevalence of tuberculosis (TB) over study clusters and households. METHODS: A nationwide, stratified cluster sample survey was carried out in 2006-2007 in Viet Nam to assess the prevalence of infection with M. tuberculosis. A representative sample of children aged 6-14 years underwent a tuberculin skin test (TST) using the Mantoux method. RESULTS: Of 23,160 children registered, 21,487 (92.8%) were tested and read and available for analysis. Using a cut-off point of 10 mm, the estimated prevalence of TST positivity was 16.7%, and the ARTI was 1.7% (95%CI 1.5-1.8). Higher infection rates were found in urban than in rural and remote areas, and infection rates increased with age. There was significant association between the prevalence of TB disease and infection at the cluster level (regression coefficient 0.54, 95%CI 0.06-1.01, P = 0.027, correlation coefficient R(2) 0.120). Children with a (recent) case of TB in the household were 1.6 times more likely to be TST-positive than children in households with no recent cases (P < 0.05). CONCLUSION: The estimated nationwide ARTI was 1.7%. TST positivity was associated with the presence of a TB case in the household.
Authors: Leonardo Martinez; Ye Shen; Ezekiel Mupere; Allan Kizza; Philip C Hill; Christopher C Whalen Journal: Am J Epidemiol Date: 2017-06-15 Impact factor: 4.897
Authors: Leonardo Martinez; Nathan C Lo; Olivia Cords; Philip C Hill; Palwasha Khan; Mark Hatherill; Anna Mandalakas; Alexander Kay; Julio Croda; C Robert Horsburgh; Heather J Zar; Jason R Andrews Journal: Lancet Respir Med Date: 2019-05-08 Impact factor: 30.700
Authors: Colleen F Hanrahan; Bareng A S Nonyane; Lesego Mmolawa; Nora S West; Tsundzukani Siwelana; Limakatso Lebina; Neil Martinson; David W Dowdy Journal: PLoS Med Date: 2019-04-30 Impact factor: 11.069
Authors: Robert J Blount; Bao Tran; Leah G Jarlsberg; Ha Phan; Van Thanh Hoang; Nhung Viet Nguyen; Deborah A Lewinsohn; Payam Nahid Journal: PLoS One Date: 2014-05-12 Impact factor: 3.240