The ventricle-brain ratio (VBR) in functional psychoses: an admixture analysis.

An admixture analysis of the ventricle-brain ratio (VBR) on the computed tomographic (CT) scans of 72 patients with functional psychosis and 50 healthy controls was made, to determine whether two distinct distributions could be demonstrated. The patients showed a more positively skewed distribution, and a significantly higher mean VBR, but there was no evidence of more than one underlying normal distribution of values. The use of VBR alone to define a biologically separate subgroup of patients is not supported.