Literature DB >> 23675999

Effects of Y27632 on keratinocyte procurement and wound healing.

V D Gandham1, R L Maddala, V Rao, J Y Jin, D L Epstein, R P Hall, J Y Zhang.   

Abstract

A number of Rho-kinase inhibitors have been developed for various clinical applications. We examined the effects of the Rho-kinase inhibitor Y27632 on keratinocyte proliferation and migration, and found that it promoted primary human keratinocyte proliferation and migration in both monolayer and skin explant cultures. In addition, topical application of Y27632 enhanced cutaneous wound closure in the majority of wounds in mice. The growth and migration effects of Y27632 appeared to be specific to keratinocytes compared with dermal fibroblasts, and required intact Jun kinase function. Y27632 seems to be a promising agent for keratinocyte procurement and wounding healing.
© 2013 British Association of Dermatologists.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23675999      PMCID： PMC3748215          DOI： 10.1111/ced.12067

Source DB:  PubMed          Journal:  Clin Exp Dermatol        ISSN： 0307-6938            Impact factor:   3.470


  10 in total

1.  Recombinant human platelet-derived growth factor and transforming growth factor-beta mediated contraction of human dermal fibroblast populated lattices is inhibited by Rho/GTPase inhibitor but does not require phosphatidylinositol-3' kinase.

Authors:  Yuan-Ping Han; Yih-Dar Nien; Warren L Garner
Journal:  Wound Repair Regen       Date:  2002 May-Jun       Impact factor: 3.617

2.  Efficient procurement of epithelial stem cells from human tissue specimens using a Rho-associated protein kinase inhibitor Y-27632.

Authors:  Atsushi Terunuma; Renuka Pudi Limgala; Christine J Park; Isha Choudhary; Jonathan C Vogel
Journal:  Tissue Eng Part A       Date:  2010-04       Impact factor: 3.845

3.  Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.

Authors:  T Ishizaki; M Uehata; I Tamechika; J Keel; K Nonomura; M Maekawa; S Narumiya
Journal:  Mol Pharmacol       Date:  2000-05       Impact factor: 4.436

4.  Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension.

Authors:  M Uehata; T Ishizaki; H Satoh; T Ono; T Kawahara; T Morishita; H Tamakawa; K Yamagami; J Inui; M Maekawa; S Narumiya
Journal:  Nature       Date:  1997-10-30       Impact factor: 49.962

5.  Human keratinocytes are efficiently immortalized by a Rho kinase inhibitor.

Authors:  Sandra Chapman; Xuefeng Liu; Craig Meyers; Richard Schlegel; Alison A McBride
Journal:  J Clin Invest       Date:  2010-07       Impact factor: 14.808

6.  Pharmacological inhibition of Rho-kinase signaling with Y-27632 blocks melanoma tumor growth.

Authors:  Alissa Routhier; Michelle Astuccio; Deanna Lahey; Nicholas Monfredo; Alyssa Johnson; William Callahan; Amy Partington; Kelly Fellows; Lori Ouellette; Sofiela Zhidro; Carrie Goodrow; Alexis Smith; Kaitlyn Sullivan; Peter Simone; Leo Le; Bora Vezuli; Micheline Zohni; Elizabeth West; Daniel Gleason; Brad Bryan
Journal:  Oncol Rep       Date:  2010-03       Impact factor: 3.906

7.  Rho kinase inhibitor y27632 alters the balance between pluripotency and early differentiation events in human embryonic stem cells.

Authors:  Kavitha Sivasubramaniyan; Rajarshi Pal; Swapnil Totey; Vijay S Bhat; Satish Totey
Journal:  Curr Stem Cell Res Ther       Date:  2010-03       Impact factor: 3.828

8.  Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation.

Authors:  Frances E Lock; Neil A Hotchin
Journal:  PLoS One       Date:  2009-12-04       Impact factor: 3.240

9.  A ROCK inhibitor permits survival of dissociated human embryonic stem cells.

Authors:  Kiichi Watanabe; Morio Ueno; Daisuke Kamiya; Ayaka Nishiyama; Michiru Matsumura; Takafumi Wataya; Jun B Takahashi; Satomi Nishikawa; Shin-ichi Nishikawa; Keiko Muguruma; Yoshiki Sasai
Journal:  Nat Biotechnol       Date:  2007-05-27       Impact factor: 54.908

10.  RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes.

Authors:  Ben Jackson; Karine Peyrollier; Esben Pedersen; Astrid Basse; Richard Karlsson; Zhipeng Wang; Tine Lefever; Alexandra M Ochsenbein; Gudula Schmidt; Klaus Aktories; Alanna Stanley; Fabio Quondamatteo; Markus Ladwein; Klemens Rottner; Jolanda van Hengel; Cord Brakebusch
Journal:  Mol Biol Cell       Date:  2011-01-05       Impact factor: 4.138
  10 in total
  5 in total

1.  Substrate deformations induce directed keratinocyte migration.

Authors:  Hoda Zarkoob; Sathivel Chinnathambi; John C Selby; Edward A Sander
Journal:  J R Soc Interface       Date:  2018-06       Impact factor: 4.118

2.  Mitogen-activated protein kinase phosphatase-3 (MKP-3) in the surgical wound is necessary for the resolution of postoperative pain in mice.

Authors:  Sladjana Skopelja-Gardner; Madhurima Saha; Perla Abigail Alvarado-Vazquez; Brenna S Liponis; Elena Martinez; E Alfonso Romero-Sandoval
Journal:  J Pain Res       Date:  2017-03-28       Impact factor: 3.133

3.  Chondroitin Sulfate Impairs Neural Stem Cell Migration Through ROCK Activation.

Authors:  Layla T Galindo; Mayara T V V Mundim; Agnes S Pinto; Gabrielly M D Chiarantin; Maíra E S Almeida; Marcelo L Lamers; Alan R Horwitz; Marinilce F Santos; Marimelia Porcionatto
Journal:  Mol Neurobiol       Date:  2017-05-05       Impact factor: 5.590

Review 4.  CRISPR-Cas9‒Based Genomic Engineering in Keratinocytes: From Technology to Application.

Authors:  Jos P H Smits; Luca D Meesters; Berber G W Maste; Huiqing Zhou; Patrick L J M Zeeuwen; Ellen H van den Bogaard
Journal:  JID Innov       Date:  2021-12-01

5.  Prolonged treatment with Y-27632 promotes the senescence of primary human dermal fibroblasts by increasing the expression of IGFBP-5 and transforming them into a CAF-like phenotype.

Authors:  Xiangyong Li; Qian Zhou; Shuangshuang Wang; Ping Wang; Juan Li; Zhiwei Xie; Chang Liu; Jie Wen; Xunwei Wu
Journal:  Aging (Albany NY)       Date:  2020-08-25       Impact factor: 5.682
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.