| Literature DB >> 23674683 |
Minh Nguyen Nguyet1, Thi Hue Kien Duong, Vu Tuan Trung, Than Ha Quyen Nguyen, Chau N B Tran, Vo Thi Long, Le Thi Dui, Hoa Lan Nguyen, Jeremy J Farrar, Edward C Holmes, Maia A Rabaa, Juliet E Bryant, Truong Thanh Nguyen, Huong Thi Cam Nguyen, Lan Thi Hong Nguyen, Mai Phuong Pham, Hung The Nguyen, Tai Thi Hue Luong, Bridget Wills, Chau Van Vinh Nguyen, Marcel Wolbers, Cameron P Simmons.
Abstract
Dengue is the most prevalent arboviral disease of humans. The host and virus variables associated with dengue virus (DENV) transmission from symptomatic dengue cases (n = 208) to Aedes aegypti mosquitoes during 407 independent exposure events was defined. The 50% mosquito infectious dose for each of DENV-1-4 ranged from 6.29 to 7.52 log10 RNA copies/mL of plasma. Increasing day of illness, declining viremia, and rising antibody titers were independently associated with reduced risk of DENV transmission. High early DENV plasma viremia levels in patients were a marker of the duration of human infectiousness, and blood meals containing high concentrations of DENV were positively associated with the prevalence of infectious mosquitoes 14 d after blood feeding. Ambulatory dengue cases had lower viremia levels compared with hospitalized dengue cases but nonetheless at levels predicted to be infectious to mosquitoes. These data define serotype-specific viremia levels that vaccines or drugs must inhibit to prevent DENV transmission.Entities:
Keywords: entomology; infectious disease; virology
Mesh：
Year: 2013 PMID： 23674683 PMCID： PMC3670336 DOI： 10.1073/pnas.1303395110
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205